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Diagnosing native liver fibrosis and esophageal varices using liver and spleen stiffness measurements in biliary atresia: a pilot study
- Source :
- Pediatric Radiology. 46:1409-1417
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Biliary atresia commonly leads to liver fibrosis and cirrhotic complications, including esophageal varices. To evaluate liver and spleen stiffness measurements using acoustic radiation force impulse (ARFI) imaging for diagnosing grade of liver fibrosis and predicting the presence of esophageal varices in patients treated for biliary atresia. ARFI imaging of the spleen and native liver was performed in 28 patients with biliary atresia. We studied the relation between ARFI imaging values and liver histology findings (n=22), upper gastrointestinal endoscopy findings (n=16) and several noninvasive test results. Diagnostic accuracy was assessed using receiver operating characteristic curve analyses. Liver stiffness measurements exhibited a significant difference among the different grades of liver fibrosis (P=0.009), and showed higher values in patients with high-risk esophageal varices than in the other patients (P=0.04). The areas under the receiver operating characteristic curves of liver stiffness measurements for liver fibrosis grades ≥ F2, ≥F3 and = F4 were 0.83, 0.93 and 0.94, respectively. Patients with high-risk esophageal varices were preferentially diagnosed by the combined liver and spleen stiffness measurements (area under the curve, 0.92). Liver and spleen stiffness measurements using ARFI imaging are potential noninvasive markers for liver fibrosis and esophageal varices in patients treated for biliary atresia.
- Subjects :
- Adult
Liver Cirrhosis
Male
medicine.medical_specialty
Adolescent
Pilot Projects
Spleen
Esophageal and Gastric Varices
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Esophageal varices
Biliary Atresia
Biliary atresia
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Child
Neuroradiology
Acoustic radiation force impulse imaging
Receiver operating characteristic
business.industry
Ultrasound
Area under the curve
Infant
medicine.disease
medicine.anatomical_structure
Child, Preschool
030220 oncology & carcinogenesis
Pediatrics, Perinatology and Child Health
Elasticity Imaging Techniques
Female
030211 gastroenterology & hepatology
Radiology
business
Subjects
Details
- ISSN :
- 14321998 and 03010449
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Pediatric Radiology
- Accession number :
- edsair.doi.dedup.....843a7fdd86b86a18aa84108364069728