Back to Search
Start Over
Involvement of T-type calcium channels in the mechanism of low dose morphine-induced hyperalgesia in adult male rats
- Source :
- Neuropeptides. 90:102185
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- It has been shown that systemic and local administration of ultra-low dose morphine induced a hyperalgesic response via mu-opioid receptors. However, its exact mechanism(s) has not fully been clarified. It is documented that mu-opioid receptors functionally couple to T-type voltage dependent Ca+2 channels. Here, we investigated the role of T-type calcium channels, amiloride and mibefradil, on the induction of low-dose morphine hyperalgesia in male Wistar rats. The data showed that morphine (0.01 μg i.t. and 1 μg/kg i.p.) could elicit hyperalgesia as assessed by the tail-flick test. Administration of amiloride (5 and 10 μg i.t.) and mibefradil (2.5 and 5 μg i.t.) completely blocked low-dose morphine-induced hyperalgesia in spinal dorsal horn. Amiloride at doses of 1 and 5 mg/kg (i.p.) and mibefradil (9 mg/kg ip) 10 min before morphine (1 μg/kg i.p.) inhibited morphine-induced hyperalgesia. Our results indicate a role for T-type calcium channels in low dose morphine-induced hyperalgesia in rats.
- Subjects :
- Male
Pain Threshold
Receptors, Opioid, mu
Pharmacology
Amiloride
Calcium Channels, T-Type
Cellular and Molecular Neuroscience
Endocrinology
medicine
Animals
Rats, Wistar
Receptor
Pain Measurement
Mibefradil
Dose-Response Relationship, Drug
Morphine
Voltage-dependent calcium channel
Endocrine and Autonomic Systems
Chemistry
Low dose
T-type calcium channel
General Medicine
Rats
Analgesics, Opioid
Posterior Horn Cells
Neurology
Hyperalgesia
medicine.symptom
Injections, Intraperitoneal
medicine.drug
Subjects
Details
- ISSN :
- 01434179
- Volume :
- 90
- Database :
- OpenAIRE
- Journal :
- Neuropeptides
- Accession number :
- edsair.doi.dedup.....8434df202935ecf89ebf32ee4a641a91