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Graphitic carbon nitride nanodots: As reductant for the synthesis of silver nanoparticles and its biothiols biosensing application
- Source :
- Biosensorsbioelectronics. 89(Pt 1)
- Publication Year :
- 2016
-
Abstract
- The graphitic carbon nitride nanodots (g-C3N4-dots) were synthesized by a simple electrochemical "tailoring" process from bulk graphitic carbon nitride (g-C3N4) under alkaline solution for the first time. Compared with the bulk g-C3N4, the novel g-C3N4-dots not only exhibit enhanced fluorescence and excellent dispersion stability in water but also show the reducibility for the reduction of Ag+ to AgNPs at 60°C. The biothiols can bound with Ag+ through formation of biothiol-Ag+ complex to consume the Ag+ and act as capping agent to prevent the growth of AgNPs, which cause the decrease of the absorption peak of the AgNPs. Therefore, an optical sensor was developed for the detection of biothiols based on the change of the plasmon resonance absorption peak of the AgNPs. The proposed method exhibits excellent sensitivity and selectivity to biothiols with low detection limit for cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) with 11.5, 16.1, and 15.5nM, respectively. This method also has been successfully applied for the detection of biothiols in human serum with satisfactory results.
- Subjects :
- Silver
Reducing agent
Biomedical Engineering
Biophysics
Analytical chemistry
Metal Nanoparticles
02 engineering and technology
Biosensing Techniques
010402 general chemistry
Photochemistry
Electrochemistry
01 natural sciences
Silver nanoparticle
chemistry.chemical_compound
Limit of Detection
Nitriles
Humans
Cysteine
Surface plasmon resonance
Homocysteine
Chemistry
Graphitic carbon nitride
General Medicine
021001 nanoscience & nanotechnology
Glutathione
0104 chemical sciences
Reducing Agents
Dispersion stability
Graphite
Nanodot
0210 nano-technology
Biosensor
Oxidation-Reduction
Biotechnology
Subjects
Details
- ISSN :
- 18734235
- Volume :
- 89
- Issue :
- Pt 1
- Database :
- OpenAIRE
- Journal :
- Biosensorsbioelectronics
- Accession number :
- edsair.doi.dedup.....842f083bc83be99561a990d5132b21ef