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A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging
- Source :
- Chemical communications (Cambridge, England). 51(37)
- Publication Year :
- 2015
-
Abstract
- Fluorescence microscopy studies using 4-morpholinoscriptaid (4MS) demonstrated rapid cellular uptake of this scriptaid analogue into the cytoplasm but no nuclear penetration. As 4MS and scriptaid have the same in vitro activity against HDACs and KASUMI-1 cells; 4MS exemplifies a rational approach to subtly modify ‘profluorogenic’ substrates for intracellular studies.
- Subjects :
- Catalysis
Structure-Activity Relationship
Cell Line, Tumor
Materials Chemistry
Fluorescence microscope
Humans
Cell Proliferation
Fluorescent Dyes
Microscopy, Confocal
Cell Death
Dose-Response Relationship, Drug
Molecular Structure
Cell growth
Chemistry
Metals and Alloys
General Chemistry
In vitro
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Cell biology
Histone Deacetylase Inhibitors
Biochemistry
Microscopy, Fluorescence
Cell culture
Cytoplasm
Cancer cell
Ceramics and Composites
Histone deacetylase
Drug Screening Assays, Antitumor
Intracellular
Subjects
Details
- ISSN :
- 1364548X
- Volume :
- 51
- Issue :
- 37
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....84289eaa7da64128fa4e4a753aca623f