Back to Search
Start Over
Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure
- Source :
- Scientific Reports
- Publication Year :
- 2016
- Publisher :
- Nature Publishing Group, 2016.
-
Abstract
- In acquired sensorineural hearing loss, such as that produced by noise or aging, there can be massive loss of the synaptic connections between cochlear sensory cells and primary sensory neurons, without loss of the sensory cells themselves. Because the cell bodies and central projections of these cochlear neurons survive for months to years, there is a long therapeutic window in which to re-establish functional connections and improve hearing ability. Here we show in noise-exposed mice that local delivery of neurotrophin-3 (NT-3) to the round window niche, 24 hours after an exposure that causes an immediate loss of up to 50% loss of synapses in the cochlear basal region, can regenerate pre- and post-synaptic elements at the hair cell / cochlear nerve interface. This synaptic regeneration, as documented by confocal microscopy of immunostained cochlear sensory epithelia, was coupled with a corresponding functional recovery, as seen in the suprathreshold amplitude of auditory brainstem response Wave 1. Cochlear delivery of neurotrophins in humans is likely achievable as an office procedure via transtympanic injection, making our results highly significant in a translational context.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Administration, Topical
Hearing Loss, Sensorineural
Context (language use)
Sensory system
Neurotrophin-3
Audiology
Article
Mice
03 medical and health sciences
0302 clinical medicine
Neurotrophin 3
otorhinolaryngologic diseases
medicine
Animals
Correction of Hearing Impairment
Multidisciplinary
Round window
biology
business.industry
Cochlear nerve
Disease Models, Animal
Treatment Outcome
030104 developmental biology
Auditory brainstem response
medicine.anatomical_structure
biology.protein
sense organs
Hair cell
business
030217 neurology & neurosurgery
Neurotrophin
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....84253fd5d605417d23c14d6f4459f004
- Full Text :
- https://doi.org/10.1038/srep24907