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Multiple organ involvement in severe fever with thrombocytopenia syndrome: an immunohistochemical finding in a fatal case
- Source :
- Virology Journal, Virology Journal, Vol 15, Iss 1, Pp 1-8 (2018)
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- s Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS bunyavirus (SFTSV), a tick borne bunyavirus. However, Immunohistochemistry of SFTS patients are not well studied. Methods We obtained multiple of tissues from a fatal case with SFTS, including blood, lungs, kidneys, heart, and spleen. The blood samples were used to isolate the causative agent for detection of viral RNA and further expression of recombinant viral protein as primary antibody. Immunohistochemistry of the heart, lungs, spleen and kidneys was used to characterize the viral antigen in tissue sections. Results A 79-year-old man, together with his wife, was admitted because of fever. Both patients were diagnosed with SFTS by the positive SFTSV RNA in the blood. The gentleman died of multiple organ failure 8 days after hospitalization. However, his wife recovered and was discharged. Immunohistochemistry indicated that SFTSV antigens were present in all studied organs including the heart, kidney, lung and spleen, of which the spleen presented with the highest amount of SFTSV antigens. The kidney was next while the heart and lungs showed lower amount of SFTSV antigens. Conclusions SFTSV can direct infect multiple organs, resulting in multiple organ failure and ultimately in an unfavorable outcome. Electronic supplementary material The online version of this article (10.1186/s12985-018-1006-7) contains supplementary material, which is available to authorized users.
- Subjects :
- Emerging infectious diseases
Male
Phlebovirus
0301 basic medicine
China
Pathology
medicine.medical_specialty
Fever
Multiple Organ Failure
Spleen
Biology
Bunyaviridae Infections
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Fatal Outcome
0302 clinical medicine
Antigen
Virology
medicine
Humans
lcsh:RC109-216
030212 general & internal medicine
Aged
Kidney
Lung
Research
medicine.disease
Thrombocytopenia
Immunohistochemistry
Tick-borne
Primary and secondary antibodies
Severe fever with thrombocytopenia syndrome
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
Emerging infectious disease
biology.protein
Bunyavirus
RNA, Viral
SFTSV
Subjects
Details
- ISSN :
- 1743422X
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Virology Journal
- Accession number :
- edsair.doi.dedup.....8421a70871df31f20cac72eefe3a1285