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Escherichia coli Isolates That Carry vat , fyuA , chuA , and yfcV Efficiently Colonize the Urinary Tract
- Source :
- Infection and Immunity. 80:4115-4122
- Publication Year :
- 2012
- Publisher :
- American Society for Microbiology, 2012.
-
Abstract
- Extraintestinal Escherichia coli (ExPEC), a heterogeneous group of pathogens, encompasses avian, neonatal meningitis, and uropathogenic E. coli strains. While several virulence factors are associated with ExPEC, there is no core set of virulence factors that can be used to definitively differentiate these pathotypes. Here we describe a multiplex of four virulence factor-encoding genes, yfcV , vat , fyuA , and chuA , highly associated with uropathogenic E. coli strains that can distinguish three groups of E. coli : diarrheagenic and animal-associated E. coli strains, human commensal and avian pathogenic E. coli strains, and uropathogenic and neonatal meningitis E. coli strains. Furthermore, human intestinal isolates that encode all four predictor genes express them during exponential growth in human urine and colonize the bladder in the mouse model of ascending urinary tract infection in higher numbers than human commensal strains that do not encode the four predictor genes ( P = 0.02), suggesting that the presence of the predictors correlates with uropathogenic potential.
- Subjects :
- DNA, Bacterial
Virulence Factors
Urinary system
Immunology
Virulence
Urine
Biology
medicine.disease_cause
Microbiology
Neonatal meningitis
Birds
Feces
Mice
Escherichia coli
medicine
Animals
Humans
Multiplex
Urinary Tract
Gene
Escherichia coli Infections
Core set
Heterogeneous group
Escherichia coli Proteins
Infant, Newborn
medicine.disease
Molecular Pathogenesis
Infectious Diseases
Carrier State
Urinary Tract Infections
Mice, Inbred CBA
Female
Parasitology
Multiplex Polymerase Chain Reaction
Subjects
Details
- ISSN :
- 10985522 and 00199567
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- Infection and Immunity
- Accession number :
- edsair.doi.dedup.....841b0123d0ef08aec2a76931f1bdd115