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KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23
- Source :
- Genomics. 47(3)
- Publication Year :
- 1998
-
Abstract
- Kinesins are microtubule-dependent molecular motors involved in intracellular transport and mitosis. Here, we report the cloning, sequencing, mapping, and expression of a novel member of the kinesin superfamily. The sequence of this newly identified human cDNA reveals an open reading frame encoding a putative protein of 792 residues. Based on its high sequence similarity to the kinesin-like molecule KIF3B, we named this protein KIF3C. KIF3C is encoded by transcripts that are distinct from the KIF3B mRNA in human, rat, and mouse and is preferentially expressed in the brain. Fluorescence in situ hybridization reveals that, in the human genome, the KIF3C gene maps to chromosome 2 at 2p23. The sequence of KIF3C predicts an unusually long insertion in the proximity of L11, a region thought to mediate microtubule binding. Taken together, these findings suggest that KIF3C is a novel kinesin-like protein that might be specifically involved in microtubule-based transport in neuronal cells.
- Subjects :
- Genetics
Gene map
Sequence Homology, Amino Acid
Molecular Sequence Data
Nucleic acid sequence
Chromosome Mapping
Gene Expression
Kinesins
Biology
Cell biology
Rats
Mice, Inbred C57BL
Open reading frame
Mice
Gene mapping
Complementary DNA
Chromosomes, Human, Pair 2
Kinesin
Animals
Humans
Human genome
Amino Acid Sequence
Cloning, Molecular
Gene
Subjects
Details
- ISSN :
- 08887543
- Volume :
- 47
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Genomics
- Accession number :
- edsair.doi.dedup.....84089ded973872025a98ab8cc176d2f6