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Modeling Aging in HIV Infection in Nonhuman Primate Models to Address an Emerging Challenge of the post-ART Era
- Publication Year :
- 2017
-
Abstract
- The advent of antiretroviral therapy (ART) has dramatically improved both quality and length of life for subjects infected with human immunodeficiency virus (HIV), delaying or preventing progression to acquired immunodeficiency syndrome (AIDS). However, the virus induces aging-related changes to the immune system which confound treatment. Additionally, the normal physiologic events that occur during aging lead to deficiencies in immunity which not only exacerbate HIV pathogenesis but also trigger a variety of comorbidities. Here, the synergistic linkage between aging and HIV infection is examined in regard to the immunological and pathological mechanisms that drive both senescence and disease progression. The use of NHPs to investigate potential therapeutic strategies to control the deleterious consequences of aging with HIV infection is also reviewed.
- Subjects :
- 0301 basic medicine
Senescence
Human immunodeficiency virus (HIV)
Biology
medicine.disease_cause
medicine.disease
Virus
Article
Pathogenesis
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Immune system
Acquired immunodeficiency syndrome (AIDS)
Immunity
Virology
Immunology
medicine
030212 general & internal medicine
Pathological
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....84056234ac9f5031ef878f654066cdce