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Severely bothersome fatigue in children and adolescents with cancer and hematopoietic stem cell transplant recipients
- Source :
- Supportive Care in Cancer. 27:2665-2671
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Objectives were to describe bothersome fatigue in children with cancer and hematopoietic stem cell (HSCT) recipients and to identify factors associated with severely bothersome fatigue. We included children ages 8–18 years treated for cancer or HSCT recipients from three groups: [1] receiving active cancer treatment and admitted to hospital for at least 3 days, [2] attending outpatient clinic for acute lymphoblastic leukemia maintenance therapy, and [3] attending outpatient clinic following treatment completion. Fatigue was measured using the Symptom Screening in Pediatrics Tool (SSPedi); severely bothersome fatigue was defined as a lot or extremely bothersome fatigue (score of 3–4 on 0–4 scale). Factors associated with severely bothersome fatigue were examined using univariate and multiple logistic regression. Of 502 children included, 414 (82.5%) reported some degree of bothersome fatigue (scores 1–4), and 123 (24.5%) reported severely bothersome fatigue (score 3 or 4). In multiple regression analysis, factors significantly associated with severely bothersome fatigue were child age 11–14 and 15–18 years vs 8–10 years (odds ratio (OR) 2.11, 95% confidence interval (CI) 1.21–3.77 and OR 2.96, 95% CI 1.66–5.44), and inpatients receiving cancer treatment vs outpatients who had completed therapy (OR 3.85, 95% CI 2.17–7.27). We found that 82.5% of children with cancer or HSCT recipients reported bothersome fatigue and 24.5% of children reported severely bothersome fatigue. Risk factors for severely bothersome fatigue were older age and inpatients receiving active cancer treatment. Future work should evaluate systematic symptom screening in clinical practice and apply interventions to reduce fatigue.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Psychological intervention
Hematopoietic stem cell transplantation
Logistic regression
Young Adult
03 medical and health sciences
0302 clinical medicine
Maintenance therapy
Risk Factors
medicine
Humans
Outpatient clinic
030212 general & internal medicine
Child
Fatigue
business.industry
Hematopoietic Stem Cell Transplantation
Cancer
Odds ratio
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Confidence interval
Logistic Models
Oncology
030220 oncology & carcinogenesis
Female
business
Subjects
Details
- ISSN :
- 14337339 and 09414355
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Supportive Care in Cancer
- Accession number :
- edsair.doi.dedup.....83ff145054c1624a45e051455d833615