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Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases
- Source :
- Antioxidants & Redox Signaling, Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
- Publication Year :
- 2021
-
Abstract
- Significance: The prevalence and incidence of age-related neurodegenerative diseases (NDDs) tend to increase along with the enhanced average of the world life expectancy. NDDs are a major cause of morbidity and disability, affecting the health care, social and economic systems with a significant impact. Critical Issues and Recent Advances: Despite the worldwide burden of NDDs and the ongoing research efforts to increase the underlying molecular mechanisms involved in NDD pathophysiologies, pharmacological therapies have been presenting merely narrow benefits. On the contrary, absent of detrimental side effects but growing merits, regular physical exercise (PE) has been considered a prone pleiotropic nonpharmacological alternative able to modulate brain structure and function, thereby stimulating a healthier and "fitness" neurological phenotype. Future Directions: This review summarizes the state of the art of some peripheral and central-related mechanisms that underlie the impact of PE on brain plasticity as well as its relevance for the prevention and/or treatment of NDDs. Nevertheless, further studies are needed to better clarify the molecular signaling pathways associated with muscle contractions-related myokines release and its plausible positive effects in the brain. In addition, particular focus of research should address the role of PE in the modulation of mitochondrial metabolism and oxidative stress in the context of NDDs.
- Subjects :
- 0301 basic medicine
Physiology
Clinical Biochemistry
Brain Structure and Function
Physical exercise
Context (language use)
Biochemistry
03 medical and health sciences
Myokine
Animals
Humans
Medicine
Exercise
Molecular Biology
General Environmental Science
Molecular signaling
030102 biochemistry & molecular biology
business.industry
Neurodegenerative Diseases
Cell Biology
3. Good health
BDNF
brain
mitochondria
myokines
oxidative stress
skeletal muscle
030104 developmental biology
Life expectancy
General Earth and Planetary Sciences
business
Neuroscience
Subjects
Details
- ISSN :
- 15230864
- Database :
- OpenAIRE
- Journal :
- Antioxidants & Redox Signaling
- Accession number :
- edsair.doi.dedup.....83f5f70ffec3c0e2b29ac6e46b251b1e
- Full Text :
- https://doi.org/10.1089/ars.2020.8075