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An exploratory cross-sectional study of subclinical vascular damage in patients with polymyalgia rheumatica
- Source :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The aim of the study was to investigate the presence of subclinical vascular damage in polymyalgia rheumatica (PMR). We enrolled PMR patients having major cardiovascular risk factors (MCVRF) and, as controls, patients with MCVRF. All underwent: color Doppler ultrasound to evaluate the common carotid intima-media thickness (IMT), the anterior–posterior abdominal aortic diameter (APAD), and the prevalence of carotid artery stenosis; the cardio-ankle vascular index (CAVI) to measure arterial stiffness together with the ankle-brachial index (ABI) to investigate the presence of lower-extremity peripheral arterial disease. Finally, we measured the serum levels of adipocytokines implicated in vascular dysfunction. As a result, 48 PMR and 56 MCVRF patients were included. An increase of IMT (1.07/0.8–1.2 vs 0.8/0.8–1.05; p = 0.0001), CAVI (8.7/7.8–9.3 vs 7.6/6.9–7.8; p 2 = 0.845 and r2 = 0.556, respectively; p
- Subjects :
- Leptin
Male
cardiovascular risk factors
Vasculitis syndromes
Comorbidity
030204 cardiovascular system & hematology
Carotid Intima-Media Thickness
polymyalgia rheumatica
0302 clinical medicine
color doppler ultrasoun
cavi
imt
adipocytokines
Risk Factors
Resistin
Aorta, Abdominal
Ultrasonography, Doppler, Color
Subclinical infection
Aged, 80 and over
education.field_of_study
Multidisciplinary
Smoking
Middle Aged
Cardiovascular Diseases
Cardiology
Medicine
Female
Adiponectin
musculoskeletal diseases
medicine.medical_specialty
Carotid Artery, Common
Science
education
Hypercholesterolemia
Population
Adipokine
Article
Polymyalgia rheumatica
Peripheral Arterial Disease
03 medical and health sciences
Vascular Stiffness
Internal medicine
Diabetes Mellitus
medicine
Humans
Ankle Brachial Index
Aged
030203 arthritis & rheumatology
business.industry
Overweight
medicine.disease
Stenosis
Cross-Sectional Studies
Case-Control Studies
Arterial stiffness
business
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....83dc382a247feacc28f454589605d703