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Periaqueductal gray neurons encode the sequential motor program in hunting behavior of mice
- Source :
- Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021), Nature Communications
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Sequential encoding of motor programs is essential for behavior generation. However, whether it is critical for instinctive behavior is still largely unknown. Mouse hunting behavior typically contains a sequential motor program, including the prey search, chase, attack, and consumption. Here, we reveal that the neuronal activity in the lateral periaqueductal gray (LPAG) follows a sequential pattern and is time-locked to different hunting actions. Optrode recordings and photoinhibition demonstrate that LPAGVgat neurons are required for the prey detection, chase and attack, while LPAGVglut2 neurons are selectively required for the attack. Ablation of inputs that could trigger hunting, including the central amygdala, the lateral hypothalamus, and the zona incerta, interrupts the activity sequence pattern and substantially impairs hunting actions. Therefore, our findings reveal that periaqueductal gray neuronal ensembles encode the sequential hunting motor program, which might provide a framework for decoding complex instinctive behaviors.<br />Hunting behavior typically contains a sequential motor program, including search, chase, attack, and consumption. Here, the authors show that periaqueductal gray neuronal ensembles encode the sequential hunting motor program, which might provide a framework for decoding complex instinctive behaviors.
- Subjects :
- Male
Lateral hypothalamus
Science
Prey detection
General Physics and Astronomy
Motor program
Biology
ENCODE
Neural circuits
Periaqueductal gray
Amygdala
Article
General Biochemistry, Genetics and Molecular Biology
Mice
Sensorimotor processing
medicine
Animals
Periaqueductal Gray
Zona Incerta
Premovement neuronal activity
Neurons
Multidisciplinary
Behavior, Animal
Electromyography
ComputingMilieux_PERSONALCOMPUTING
General Chemistry
Immunohistochemistry
medicine.anatomical_structure
Hypothalamic Area, Lateral
Zona incerta
Open Field Test
Neuroscience
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....83d23402960d9f2c5462cd5fc6675b8f