Back to Search
Start Over
Pulmonary artery/aorta ratio in simple screening for fetal outflow tract abnormalities during the second trimester
Pulmonary artery/aorta ratio in simple screening for fetal outflow tract abnormalities during the second trimester
- Source :
- Ultrasound in obstetricsgynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 30(3)
- Publication Year :
- 2007
-
Abstract
- Objectives: Congenital heart disease is associated with high mortality and morbidity rates, being the most life-threatening defect in the first month of postnatal life and accounting for approximately half of all childhood mortality from birth defects. Despite this, the prenatal detection rate for congenital outflow tract anomalies by ultrasound imaging is relatively low. The aim of this study was to establish a nomogram for the pulmonary artery/aorta (PA/AO) ratio measured in the three-vessel view plane. This ratio was investigated as a simple screening tool for congenital cardiac outflow tract abnormalities. Methods: The study was a prospective evaluation of 966 singleton fetuses at 16-24 weeks of gestation and 46 fetuses with congenital cardiac outflow tract abnormalities. The diameters of the pulmonary artery and aorta were measured in the three-vessel view. The PAIAO ratio was calculated and a nomogram was constructed. The mean and 95% CI for the ratio were defined and the PA/AO ratios of cases with outflow tract abnormalities were plotted against the values for normal fetuses. Results: The gestational age of the normal group ranged from 16 to 24 weeks, with a median of 19 weeks. The pulmonary artery diameter measured between 2.1 and 4.93 mm (mean, 3.3 mm) and the aorta measured between 2.1 and 5.2 mm (mean, 2.93 mm). The mean (SD) PA/AO ratio was 1.16 (0.18) (95% CI, 0.87-1.58; range 0.61-1.86; median, 1.14). For fetuses with outflow tract abnormalities, the median gestation was 19 weeks and 3 7/43 (86%) had a PA/AO ratio outside the 95% CI. Conclusions: The PA/AO ratio derived from measurements in the three-vessel view plane can be used as an initial screening tool for outflow tract anomalies and may have a sensitivity of up to 86%, with a 5% false-positive rate.
- Subjects :
- Heart Defects, Congenital
medicine.medical_specialty
Prenatal diagnosis
Gestational Age
Pulmonary Artery
Ultrasonography, Prenatal
Fetal Heart
Pregnancy
Internal medicine
medicine.artery
medicine
Humans
Mass Screening
Radiology, Nuclear Medicine and imaging
Prospective Studies
Aorta
Observer Variation
Fetus
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Obstetrics and Gynecology
Gestational age
General Medicine
Surgery
Fetal Diseases
Reproductive Medicine
Great arteries
Pregnancy Trimester, Second
Circulatory system
Pulmonary artery
Cardiology
Female
business
Fetal echocardiography
Subjects
Details
- ISSN :
- 09607692
- Volume :
- 30
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Ultrasound in obstetricsgynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
- Accession number :
- edsair.doi.dedup.....83cdce483693edadf5cec3449c6c0663