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Intrinsic Connectivity Network-Based Classification and Detection of Psychotic Symptoms in Youth With 22q11.2 Deletions
- Source :
- Cerebral cortex (New York, N.Y. : 1991), vol 27, iss 6
- Publication Year :
- 2017
- Publisher :
- eScholarship, University of California, 2017.
-
Abstract
- 22q11.2 Deletion syndrome (22q11DS) is a genetic disorder associated with numerous phenotypic consequences and is one of the greatest known risk factors for psychosis. We investigated intrinsic-connectivity-networks (ICNs) as potential biomarkers for patient and psychosis-risk status in 2 independent cohorts, UCLA (33 22q11DS-participants, 33 demographically matched controls), and Syracuse (28 22q11DS, 28 controls). After assessing group connectivity differences, ICNs from the UCLA cohort were used to train classifiers to distinguish cases from controls, and to predict psychosis risk status within 22q11DS; classifiers were subsequently tested on the Syracuse cohort. In both cohorts we observed significant hypoconnectivity in 22q11DS relative to controls within anterior cingulate (ACC)/precuneus, executive, default mode (DMN), posterior DMN, and salience networks. Of 12 ICN-derived classifiers tested in the Syracuse replication-cohort, the ACC/precuneus, DMN, and posterior DMN classifiers accurately distinguished between 22q11DS and controls. Within 22q11DS subjects, connectivity alterations within 4 networks predicted psychosis risk status for a given individual in both cohorts: the ACC/precuneus, DMN, left executive, and salience networks. Widespread within-network-hypoconnectivity in large-scale networks implicated in higher-order cognition may be a defining characteristic of 22q11DS during adolescence and early adulthood; furthermore, loss of coherence within these networks may be a valuable biomarker for individual prediction of psychosis-risk in 22q11DS.
- Subjects :
- Male
Precuneus
Audiology
Neuropsychological Tests
Cohort Studies
0302 clinical medicine
velocardiofacial syndrome
Parietal Lobe
Psychology
psychosis
Child
Default mode network
Pediatric
Cognition
Experimental Psychology
Serious Mental Illness
Magnetic Resonance Imaging
medicine.anatomical_structure
machine learning
Mental Health
Cohort
intrinsic connectivity networks
Female
Cognitive Sciences
Psychosis
medicine.medical_specialty
Adolescent
Cognitive Neuroscience
resting state functional MRI
Gyrus Cinguli
03 medical and health sciences
Cellular and Molecular Neuroscience
Motion
Young Adult
Salience (neuroscience)
Clinical Research
medicine
DiGeorge Syndrome
Connectome
Humans
Deletion syndrome
Psychiatry
Psychiatric Status Rating Scales
Prevention
Neurosciences
Original Articles
medicine.disease
030227 psychiatry
Brain Disorders
Oxygen
Psychotic Disorders
Potential biomarkers
Case-Control Studies
Nerve Net
human activities
030217 neurology & neurosurgery
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Cerebral cortex (New York, N.Y. : 1991), vol 27, iss 6
- Accession number :
- edsair.doi.dedup.....83c0e6cd17ba2e072eb01419b336927b