Back to Search
Start Over
Comparison of Traditional and Ultrasound-Enhanced Electrospinning in Fabricating Nanofibrous Drug Delivery Systems
- Source :
- Pharmaceutics, Volume 11, Issue 10, Pharmaceutics, Vol 11, Iss 10, p 495 (2019)
- Publication Year :
- 2019
- Publisher :
- MDPI, 2019.
-
Abstract
- We investigated nozzleless ultrasound-enhanced electrospinning (USES) as means to generate nanofibrous drug delivery systems (DDSs) for pharmaceutical and biomedical applications. Traditional electrospinning (TES) equipped with a conventional spinneret was used as a reference method. High-molecular polyethylene oxide (PEO) and chitosan were used as carrier polymers and theophylline anhydrate as a water-soluble model drug. The nanofibers were electrospun with the diluted mixture (7:3) of aqueous acetic acid (90% v/v) and formic acid solution (90% v/v) (with a total solid content of 3% w/v). The fiber diameter and morphology of the nanofibrous DDSs were modulated by varying ultrasonic parameters in the USES process (i.e., frequency, pulse repetition frequency and cycles per pulse). We found that the USES technology produced nanofibers with higher fiber diameter (402 &plusmn<br />127 nm) than TES (77 &plusmn<br />21 nm). An increase of a burst count in USES increased the fiber diameter (555 &plusmn<br />265 nm) and the variation in fiber size. The slight-to-moderate changes in a solid state (crystallinity) were detected when compared the nanofibers generated by TES and USES. In conclusion, USES provides a promising alternative for aqueous-based fabrication of nanofibrous DDSs for pharmaceutical and biomedical applications.
- Subjects :
- Materials science
Formic acid
Drug delivery system
Nanofibers
Pharmaceutical Science
lcsh:RS1-441
02 engineering and technology
01 natural sciences
Article
Chitosan
lcsh:Pharmacy and materia medica
chemistry.chemical_compound
Crystallinity
nanofibers
Nanotechnology
drug delivery system
chemistry.chemical_classification
Aqueous solution
nanotechnology
010405 organic chemistry
Ultrasound-enhanced electrospinning
Polymer
021001 nanoscience & nanotechnology
ultrasound-enhanced electrospinning
Electrospinning
0104 chemical sciences
chemistry
Chemical engineering
317 Pharmacy
Nanofiber
Drug delivery
221 Nano-technology
nanotechnology, nanofibers, traditional electrospinning, ultrasound-enhanced electrospinning, drug delivery system
Traditional electrospinning
0210 nano-technology
traditional electrospinning
Subjects
Details
- Language :
- English
- ISSN :
- 19994923
- Volume :
- 11
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Pharmaceutics
- Accession number :
- edsair.doi.dedup.....83b2cb9e23f7959e6487b804c054c4e4