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Lack of efficacy of a starch-thickened preterm formula on gastro-oesophageal reflux in preterm infants: a pilot study
- Publication Year :
- 2012
-
Abstract
- BACKGROUND: Gastro-oesophageal reflux (GOR) is common in preterm infants; conservative interventions (i.e. dietary changes) should represent the first-line approach. AIM: To evaluate by combined pH and impedance monitoring (pH-MII) the effect of a new preterm formula thickened with amylopectin (TPF) on GOR features in symptomatic preterm infants. METHODS: Twenty-eight symptomatic preterm newborns underwent a 24-hour pH-MII; each baby received eight meals (four of TPF and four of a preterm formula [PF]). GOR indexes (number, acidity, duration and height of GORs) after TPF and PF meals were compared by Wilcoxon Signed Ranks Test. Viscosity of PF and TPF was measured. RESULTS: TPF significantly decreased the number of acid GORs detected by pH-monitoring (TPF vs. PF: median 20 vs. 24.5, p = 0.009), while it had no influence on Reflux Index (RIpH), nor on acid and non-acid GOR indexes detected by MII, GOR physical features, and GOR height. TPF's viscosity was extremely higher than PF's, and further increased at pH 3 after the addition of pepsin. CONCLUSIONS: The new formula was found to reduce the number of acid GORs detected by pH-monitoring; it did not reduce neither total oesophageal acid exposure nor non-acid GORs. At present its extended clinical use cannot be recommended.
- Subjects :
- Male
medicine.medical_specialty
Pediatrics
Treatment outcome
Gestational Age
Pilot Projects
Infant, Premature, Diseases
Gastroenterology
Esophagus
Gastro
Internal medicine
PRETERM INFANTS
Electric Impedance
medicine
Lack of efficacy
Humans
gastro-esophageal reflux
business.industry
Infant, Newborn
Reflux
Obstetrics and Gynecology
Gestational age
Starch
Hydrogen-Ion Concentration
Infant Formula
feed thickening
Treatment Outcome
Dietary Supplements
Food, Fortified
Pediatrics, Perinatology and Child Health
Gastroesophageal Reflux
Female
business
Infant, Premature
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....83b14d4afca67e95f6b1c5ee07d6d082