Sustained Decrease in Gastroenteritis-related Deaths and Hospitalizations in Children Less Than 5 Years of Age After the Introduction of Rotavirus Vaccination: A Time-Trend Analysis in Brazil (2001-2010)

Secretaria de Sa?de do Estado do Par?. Department of Epidemiology. Bel?m, PA, Brazil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Secretaria de Sa?de do Estado do Par?. Department of Epidemiology. Bel?m, PA, Brazil. GSK Vaccines. Rio de Janeiro, RJ, Brazil. GSK Vaccines. Regional Office. Epidemiology and Health Outcomes. Panam?. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. GSK Pharmaceuticals. Research & Development. Bangalore, India GSK Vaccines. Regional Office. VxR&D Medical. Panam?. GSK Vaccines. VxR&D Medical & Clinical Latin America. Rio de Janeiro, RJ, Brazil. Background: Rotavirus (RV) vaccine, Rotarix, was introduced into the Brazil national immunization program in 2006. To estimate populationlevel vaccine effect, we conducted a time?trend analysis on all-cause gastroenteritis (GE)-related death certificate?reported deaths (DCRDs), hospital deaths (HDs) and hospitalizations trends in