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Perilimbal sclera mechanical properties: Impact on intraocular pressure in porcine eyes
- Source :
- PLoS ONE, Vol 13, Iss 5, p e0195882 (2018), PLoS ONE
- Publication Year :
- 2018
- Publisher :
- Public Library of Science (PLoS), 2018.
-
Abstract
- There is extensive knowledge on the relationship of posterior scleral biomechanics and intraocular pressure (IOP) load on glaucomatous optic neuropathy; however, the role for biomechanical influence of the perilimbal scleral tissue on the aqueous humor drainage pathway, including the distal venous outflow system, and IOP regulation is not fully understood. The purpose of this work is to study the outflow characteristics of perfused porcine eyes relative to the biomechanical properties of the perilimbal sclera, the posterior sclera and the cornea. Enucleated porcine eyes from eleven different animals were perfused with surrogate aqueous at two fixed flow rates while monitoring their IOP. After perfusion, mechanical stress-strain and relaxation tests were conducted on specimens of perilimbal sclera, posterior sclera, and cornea from the same perfused eyes. Statistical analysis of the data demonstrated a strong correlation between increased tangent modulus of the perilimbal sclera tissues and increased perfusion IOP (R2 = 0.74, p = 0.0006 at lower flow rate and R2 = 0.71, p = 0.0011 at higher flow rate). In contrast, there were no significant correlations between IOP and the tangent modulus of the other tissues (Posterior sclera: R2 = 0.17 at lower flow rate and R2 = 0.30 at higher flow rate; cornea: R2 = 0.02 at lower flow rate and R2
- Subjects :
- 0301 basic medicine
Intraocular pressure
genetic structures
Swine
lcsh:Medicine
Stiffness
Cornea
0302 clinical medicine
Materials Testing
Medicine and Health Sciences
Relaxation Time
Statistical analysis
lcsh:Science
Flow Rate
Multidisciplinary
Viscosity
Physics
Biomechanics
Classical Mechanics
Sclera
Biomechanical Phenomena
medicine.anatomical_structure
Tangent modulus
Physical Sciences
Mechanical Stress
Anatomy
Perfusion
Research Article
medicine.medical_specialty
Ocular Anatomy
Materials Science
Material Properties
Geometry
Fluid Mechanics
Continuum Mechanics
Veins
03 medical and health sciences
Ocular System
Ophthalmology
medicine
Tangents
Animals
Mechanical Properties
Relaxation (Physics)
Intraocular Pressure
Mechanical Phenomena
business.industry
lcsh:R
Biology and Life Sciences
Fluid Dynamics
Elasticity
eye diseases
030104 developmental biology
030221 ophthalmology & optometry
Cardiovascular Anatomy
Eyes
Blood Vessels
lcsh:Q
sense organs
Tissue stiffness
business
Head
Mathematics
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....839fdced7390694e011b3397aaa43166