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Sleep-disordered Breathing in Pregnancy and after Delivery: Associations with Cardiometabolic Health
- Source :
- Am J Respir Crit Care Med, American journal of respiratory and critical care medicine, vol 205, iss 10
- Publication Year :
- 2022
- Publisher :
- American Thoracic Society, 2022.
-
Abstract
- Rationale: Knowledge gaps exist regarding health implications of sleep-disordered breathing (SDB) identified in pregnancy and/or after delivery. Objectives: To determine whether SDB in pregnancy and/or after delivery is associated with hypertension (HTN) and metabolic syndrome (MS). Methods: nuMoM2b-HHS (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be Heart Health Study) (N = 4,508) followed participants initially recruited during their first pregnancy. Participants returned for a visit 2-7 years after pregnancy. This study examined a subgroup who underwent SDB assessments during their first pregnancy (n = 1,964) and a repeat SDB assessment after delivery (n = 1,222). Two SDB definitions were considered: 1) apnea-hypopnea index (AHI) ⩾ 5 and 2)oxygen desaturation index (ODI) ⩾ 5. Associations between SDB and incident HTN and MS were evaluated with adjusted risk ratios (aRRs). Measurements and Main Results: The aRR for MS given an AHI ⩾ 5 during pregnancy was 1.44 (95% confidence interval [CI], 1.08-1.93), but no association with HTN was found. ODI ⩾ 5 in pregnancy was associated with both an increased risk for HTN (aRR, 2.02; 95% CI, 1.30-3.14) and MS (aRR, 1.53; 95% CI, 1.19-1.97). Participants with an AHI ⩾ 5 in pregnancy that persisted after delivery were at higher risk for both HTN (aRR, 3.77; 95% CI, 1.84-7.73) and MS (aRR, 2.46; 95% CI, 1.59-3.76). Similar associations were observed for persistent ODI ⩾ 5 after delivery. Conclusions: An AHI ⩾ 5 in pregnancy was associated with an increased risk of MS. An ODI ⩾ 5 in pregnancy was significantly associated with both HTN and MS. Participants with persistent elevations in AHI and ODI during pregnancy and at 2-7 years after delivery were at the highest risk for HTN and MS. Clinical trial registered with www.clinicaltrials.gov (NCT02231398).
- Subjects :
- Pulmonary and Respiratory Medicine
hypertension
Polysomnography
Respiratory System
Reproductive health and childbirth
Cardiovascular
Critical Care and Intensive Care Medicine
Medical and Health Sciences
sleep disordered breathing
Sleep Apnea Syndromes
Clinical Research
Pregnancy
Risk Factors
Odds Ratio
Humans
postpartum
Lung
Prevention
sleep-disordered breathing
Original Articles
Oxygen
Good Health and Well Being
Cardiovascular Diseases
Female
Sleep Research
cardiometabolic health
Subjects
Details
- ISSN :
- 15354970 and 1073449X
- Volume :
- 205
- Database :
- OpenAIRE
- Journal :
- American Journal of Respiratory and Critical Care Medicine
- Accession number :
- edsair.doi.dedup.....837b3c9714c84f4e4b1748305e8c7c9c