Inflammatory prognostic index score as a new parameter predicting overall survival in renal cell carcinoma

Background/Aim: The importance of prognostic markers in the treatment and follow-up of metastatic renal cell carcinoma is gradually increasing. Currently used markers do not meet the exact needs in this regard. In this study, we evaluated the predictive and prognostic values of inflammatory prognostic index (IPI) scoring in metastatic Renal cell carcinoma (RCC) patients. In IPI scoring, we used four biochemical parameters related to inflammation, including albumin, CRP, neutrophils, and lymphocytes. Methods: Medical records of fifty-seven patients with RCC treated in Celal Bayar University Medical Faculty Hospital Medical Oncology Clinic between February 2012 and April 2019 were retrospectively reviewed. The IPI was calculated as C-reactive protein × NLR (neutrophil/lymphocyte ratio)/serum albumin. Univariate and multivariate analyses were performed to assess the prognostic value of relevant factors. Results: The cut-off value for IPI in predicting mortality was 1.03 according to ROC curve analysis. Median OS of the patients with IPI ≥1.03 was 8 months (95 %Cl 3-10.9). The relationship between overall survival and IPI score was remarkable. According to this analysis, comorbidity, metastasis to the lung, liver, lymph nodes, bone, the number of metastatic sites (one metastatic area), high NLR, high IPI were also significantly associated with OS (P1.03) had an increased mortality risk compared to those with low IPI (