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Genes associated with Parkinson's disease: regulation of autophagy and beyond
- Source :
- Journal of Neurochemistry. 139:91-107
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Substantial progress has been made in the genetic basis of Parkinson's disease (PD). In particular, by identifying genes that segregate with inherited PD or show robust association with sporadic disease, and by showing the same genes are found on both lists, we have generated an outline of the cause of this condition. Here, we will discuss what those genes tell us about the underlying biology of PD. We specifically discuss the relationships between protein products of PD genes and show that common links include regulation of the autophagy-lysosome system, an important way by which cells recycle proteins and organelles. We also discuss whether all PD genes should be considered to be in the same pathway and propose that in some cases the relationships are closer, whereas in other cases the interactions are more distant and might be considered separate. Beilina and Cookson review the links between genes for Parkinson's disease (red) and the autophagy-lysosomal system. They propose the hypothesis that many of the known PD genes can be assigned to pathways that affect (I) turnover of mitochondria via mitophagy (II) turnover of several vesicular structures via macroautophagy or chaperone-mediated autophagy or (III) general lysosome function. This article is part of a special issue on Parkinson disease.
- Subjects :
- 0301 basic medicine
Parkinson's disease
Disease
Mitochondrion
Biology
Biochemistry
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Chaperone-mediated autophagy
Lysosome
Mitophagy
Autophagy
medicine
Animals
Humans
Genetic Predisposition to Disease
Gene
Genetics
Parkinson Disease
medicine.disease
Mitochondria
030104 developmental biology
medicine.anatomical_structure
Lysosomes
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00223042
- Volume :
- 139
- Database :
- OpenAIRE
- Journal :
- Journal of Neurochemistry
- Accession number :
- edsair.doi.dedup.....834d34042081a2a2cd581fb069955066