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Relationships between tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and hematopoietic activity in healthy adults
- Source :
- Annals of Hematology. 84:728-733
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- To investigate the relationship between hematopoiesis and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), we measured soluble TRAIL concentrations, reticulocytes, hemograms, and anthropometric variables in 156 healthy subjects. Serum TRAIL concentrations were analyzed by an enzyme immunoassay. Serum ferritin, thyroid hormone, total cholesterol, creatinine, and blood glucose levels were determined. There were no significant differences in blood cell counts and biochemical parameters between the subjects with TRAIL less than 63.5 pg/ml and TRAIL at least 63.5 pg/ml, nor between those with TRAIL at most 47.5 pg/ml (20th percentile) and TRAILor =80.9 pg/ml (80th percentile). However, hemoglobin, mean corpuscular hemoglobin (MCH), and MCH concentration (MCHC) averaged 15.6+/-0.8 g/dl, 31.9+/-1.1 pg, and 34.5+/-0.9 g/dl in the subjects with TRAIL at most 47.5 pg/ml, which were significantly above the values in those with TRAIL at least 80.9 pg/ml (14.7+/-0.9 g/dl, 30.4+/-1.3 pg, and 33.2+/-1.2 g/dl, P0.05, respectively). Serum TRAIL levels were significantly higher in the subjects with decreased MCH than in those with elevated MCH. Soluble TRAIL concentrations were significantly correlated with hemoglobin (r=-0.25, P0.05), MCH (r=-0.32, P0.05), and MCHC (r=-0.29, P0.05), but not correlated with leukocyte differentials and platelet counts. In conclusion, soluble TRAIL does not seem to influence leukocyte and platelet production but has an important relationship to erythropoiesis in healthy adults.
- Subjects :
- Adult
medicine.medical_specialty
Mean corpuscular hemoglobin
TNF-Related Apoptosis-Inducing Ligand
Blood cell
Hemoglobins
Leukocyte Count
chemistry.chemical_compound
Reference Values
Internal medicine
medicine
Humans
Erythropoiesis
Platelet
Aged
Creatinine
Membrane Glycoproteins
Hematology
medicine.diagnostic_test
Platelet Count
Tumor Necrosis Factor-alpha
RED-CELL INDICES
business.industry
General Medicine
Middle Aged
Hematopoiesis
Endocrinology
medicine.anatomical_structure
chemistry
Hemoglobin
Apoptosis Regulatory Proteins
business
Subjects
Details
- ISSN :
- 14320584 and 09395555
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- Annals of Hematology
- Accession number :
- edsair.doi.dedup.....83481a9125d5bfb389d378d7c7efc24e