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Fish allergy tolerance 16 months after diagnosis
- Source :
- Allergologia et Immunopathologia. 49:25-27
- Publication Year :
- 2021
- Publisher :
- Codon Publications, 2021.
-
Abstract
- Fish allergy is generally thought to be persistent, and approximately 80% of patients with fish allergies do not develop tolerance even 10 years after diagnosis. There have been no reports of rapid tolerance development in patients with severe fish allergies. We report the development of tolerance 16 months after the diagnosis of fish allergies. A 13-month-old boy was diagnosed with rosefish allergy (Sebastes matsubarae) and Japanese jack mackerel allergy (Trachurus japonicus). To find out which species of fish he could consume safely, he under-went several oral food challenge (OFC) tests. It was determined that he could consume tuna, salmon, cod, sardine, chub mackerel (Scomber japonicus), and Japanese amberjack (Seriola quinqueradiata) without eliciting signs of allergy. He continued to eat the fish that did not produce allergic reactions three to four times a week. The titer of serum allergen-specific immunoglobulin E (IgE) to fish had decreased in a subsequent ImmunoCAP®-specific IgE blood test performed 16 months after the diagnosis of the rosefish allergy. Following this test result, he underwent OFCs with rosefish and Japanese jack mackerel, both of which turned out to be negative, and it was determined that he had developed tolerance to fish. In this case, the repeated OFCs were useful in identifying fish species that were safe for consumption. In addition, the decrease in allergen-specific IgE was useful in predicting the development of tol-erance. We hypothesize that proactive consumption of available fish species may lead to this rapid induction of tolerance to fish allergens.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
Allergy
Immunology
Physiology
food
Chub mackerel
Animals
Humans
Immunology and Allergy
Medicine
Amberjack
Skin Tests
biology
business.industry
Oral food challenge
Sardine
Fishes
Jack mackerel
Infant
General Medicine
Allergens
Immunoglobulin E
biology.organism_classification
medicine.disease
food.food
Trachurus japonicus
Seriola quinqueradiata
business
Food Hypersensitivity
Subjects
Details
- ISSN :
- 03010546
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Allergologia et Immunopathologia
- Accession number :
- edsair.doi.dedup.....834790ebc954552bcc74c3be60960f9f