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Frailty index predicts poor outcome in COVID-19 patients
- Source :
- Intensive Care Medicine
- Publication Year :
- 2020
- Publisher :
- Springer, 2020.
-
Abstract
- Functional status and chronic health status are important baseline characteristics of critically ill patients. The assessment of frailty on admission to the intensive care unit (ICU) may provide objective, prognostic information on baseline health. To determine the impact of frailty on the outcome of critically ill patients, we performed a systematic review and meta-analysis comparing clinical outcomes in frail and non-frail patients admitted to ICU.We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, PubMed, CINAHL, and Clinicaltrials.gov. All study designs with the exception of narrative reviews, case reports, and editorials were included. Included studies assessed frailty in patients greater than 18 years of age admitted to an ICU and compared outcomes between fit and frail patients. Two reviewers independently applied eligibility criteria, assessed quality, and extracted data. The primary outcomes were hospital and long-term mortality. We also determined the prevalence of frailty, the impact on other patient-centered outcomes such as discharge disposition, and health service utilization such as length of stay.Ten observational studies enrolling a total of 3030 patients (927 frail and 2103 fit patients) were included. The overall quality of studies was moderate. Frailty was associated with higher hospital mortality [relative risk (RR) 1.71; 95% CI 1.43, 2.05; p 0.00001; IFrailty is common in patients admitted to ICU and is associated with worsened outcomes. Identification of this previously unrecognized and vulnerable ICU population should act as the impetus for investigating and implementing appropriate care plans for critically ill frail patients. Registration: PROSPERO (ID: CRD42016053910).
- Subjects :
- Adult
2019-20 coronavirus outbreak
medicine.medical_specialty
Letter
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Critical Illness
Pneumonia, Viral
Frailty Index
Critical Care and Intensive Care Medicine
Outcome (game theory)
Severity of Illness Index
Betacoronavirus
Risk Factors
Anesthesiology
Internal medicine
Correspondence
Prevalence
Medicine
Humans
Hospital Mortality
Prospective Studies
Pandemics
Frailty
SARS-CoV-2
business.industry
Age Factors
COVID-19
Length of Stay
Intensive Care Units
Observational Studies as Topic
Treatment Outcome
Coronavirus Infections
business
Subjects
Details
- Language :
- English
- ISSN :
- 42016053
- Database :
- OpenAIRE
- Journal :
- Intensive Care Medicine
- Accession number :
- edsair.doi.dedup.....833b69d68c8ce024d04ef8f8bc1aaa09