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Comparison of Sectoral Structure-Function Relationships in Glaucoma: Vessel Density Versus Thickness in the Peripapillary Retinal Nerve Fiber Layer
- Source :
- Investigative Opthalmology & Visual Science. 58:5251
- Publication Year :
- 2017
- Publisher :
- Association for Research in Vision and Ophthalmology (ARVO), 2017.
-
Abstract
- Purpose To compare the sectoral structure-function relationships in glaucoma between two structural parameters, vessel density (VD) and thickness, in the peripapillary retinal nerve fiber layer (RNFL). Methods Optical coherence tomography (OCT) angiography (AngioVue/RTVue-XR) for VD and OCT (RS-3000) for peripapillary RNFL thickness were performed in 129 eyes from 129 subjects (94 glaucoma, 17 glaucoma suspects, and 18 normal eyes). Humphrey visual field (VF) tests were performed using a SITA standard 24-2 program. Sectoral structure-function relationships based on the Garway-Heath map were compared between VD and thickness using a semipartial correlation coefficient (sr) and partial residual plots determined by multiple linear regression models controlling for the effects of sex, age, axial length, disc area, beta- and gamma- parapapillary atrophy (PPA) zones, and signal strength index (SSI). Results For all VF sectors, the sr2 of VD was largest when the VD sector corresponded to the VF sector (sr2: 0.17-0.39). In contrast, in only three sectors was the sr2 of thickness largest when the thickness sector corresponded to the VF sector (sr2: 0.02-0.34): the inferior temporal, temporal, and superior temporal sectors. The partial residual plots against VD showed more linear relationships with VF sensitivity than those against thickness in the qualitative evaluation of fitting by locally weighted scatterplot smoothing. Eyes with larger SSI had higher VD, whereas eyes with a larger extension of the PPA zone into the VD measurement area had lower VD. Conclusions Peripapillary RNFL VD and thickness have different characteristic sectoral structure-function relationships in glaucoma.
- Subjects :
- Male
Retinal Ganglion Cells
0301 basic medicine
medicine.medical_specialty
genetic structures
Correlation coefficient
media_common.quotation_subject
Optic Disk
Gonioscopy
Nerve fiber layer
Glaucoma
Tonometry, Ocular
03 medical and health sciences
chemistry.chemical_compound
Nerve Fibers
0302 clinical medicine
Vessel density
Optical coherence tomography
Ophthalmology
Linear regression
medicine
Humans
Contrast (vision)
Intraocular Pressure
Mathematics
media_common
medicine.diagnostic_test
Retinal Vessels
Retinal
Middle Aged
medicine.disease
eye diseases
Axial Length, Eye
Cross-Sectional Studies
030104 developmental biology
medicine.anatomical_structure
chemistry
030221 ophthalmology & optometry
Visual Field Tests
Female
Ocular Hypertension
sense organs
Visual Fields
Glaucoma, Open-Angle
Tomography, Optical Coherence
Subjects
Details
- ISSN :
- 15525783
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Investigative Opthalmology & Visual Science
- Accession number :
- edsair.doi.dedup.....832abecc548675a736e1c2e9b19f3858