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Expression of the breast cancer metastasis suppressor gene, BRMS1, in human breast carcinoma: lack of correlation with metastasis to axillary lymph nodes

Expression of the breast cancer metastasis suppressor gene, BRMS1, in human breast carcinoma: lack of correlation with metastasis to axillary lymph nodes

Authors :
Arnold D.K. Hill
L. M. Kelly
Catherine Duggan
Yvonne Buggy
Michael J. Duffy
Niall O'Higgins
Leonie S. Young
Enda W. McDermott
Norma O'Donovan
Source :
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 26(4)
Publication Year :
2004

Abstract

The BRMS1 (breast cancer metastasis suppressor 1) gene has been found to suppress metastasis in animal models without inhibiting primary tumor growth. The aim of this study was to measure expression of BRMS1 mRNA in a panel of human breast carcinomas and compare its expression with parameters of local dissemination such as tumor size and lymph node metastasis. We also compared expression of BRMS1 mRNA in normal breast tissue, fibroadenomas, primary breast cancers and axillary nodal metastases from primary breast cancers. BRMS1 mRNA was detected in 10/11 (90%) specimens of normal breast tissue, 12/16 (75%) fibroadenomas, 64/82 (78%) primary breast cancer and 11/15 (64%) lymph node metastases (p, NS). In the primary cancer, expression was independent of tumor size, tumor grade, metastasis to axillary nodes and hormone receptor status. Furthermore, similar levels of BRMS1 were found in normal breast tissue, primary breast carcinomas and lymph node metastases from primary breast cancer. Our results do not suggest a role for BRMS1 in suppressing metastasis to local lymph nodes in patients with breast cancer.

Details

ISSN :
10104283
Volume :
26
Issue :
4
Database :
OpenAIRE
Journal :
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Accession number :
edsair.doi.dedup.....832878ec03b421b1244e6c6a80d44441