Back to Search
Start Over
Expression of the breast cancer metastasis suppressor gene, BRMS1, in human breast carcinoma: lack of correlation with metastasis to axillary lymph nodes
Expression of the breast cancer metastasis suppressor gene, BRMS1, in human breast carcinoma: lack of correlation with metastasis to axillary lymph nodes
- Source :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 26(4)
- Publication Year :
- 2004
-
Abstract
- The BRMS1 (breast cancer metastasis suppressor 1) gene has been found to suppress metastasis in animal models without inhibiting primary tumor growth. The aim of this study was to measure expression of BRMS1 mRNA in a panel of human breast carcinomas and compare its expression with parameters of local dissemination such as tumor size and lymph node metastasis. We also compared expression of BRMS1 mRNA in normal breast tissue, fibroadenomas, primary breast cancers and axillary nodal metastases from primary breast cancers. BRMS1 mRNA was detected in 10/11 (90%) specimens of normal breast tissue, 12/16 (75%) fibroadenomas, 64/82 (78%) primary breast cancer and 11/15 (64%) lymph node metastases (p, NS). In the primary cancer, expression was independent of tumor size, tumor grade, metastasis to axillary nodes and hormone receptor status. Furthermore, similar levels of BRMS1 were found in normal breast tissue, primary breast carcinomas and lymph node metastases from primary breast cancer. Our results do not suggest a role for BRMS1 in suppressing metastasis to local lymph nodes in patients with breast cancer.
- Subjects :
- Oncology
CA15-3
medicine.medical_specialty
Axillary lymph nodes
CA 15-3
Breast Neoplasms
Polymerase Chain Reaction
Metastasis
Breast cancer
Internal medicine
medicine
Humans
RNA, Messenger
skin and connective tissue diseases
Mammary Glands, Human
business.industry
Cancer
General Medicine
medicine.disease
Primary tumor
Neoplasm Proteins
Repressor Proteins
medicine.anatomical_structure
Breast Cancer Metastasis-Suppressor 1
Fibroadenoma
Lymphatic Metastasis
Axilla
Female
business
Subjects
Details
- ISSN :
- 10104283
- Volume :
- 26
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Accession number :
- edsair.doi.dedup.....832878ec03b421b1244e6c6a80d44441