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Association of age with 10-year outcomes after coronary surgery in the Arterial Revascularization Trial
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Background The association of age with the outcomes of bilateral internal thoracic arteries (BITAs) versus single internal thoracic arteries (SITAs) for coronary bypass grafting (CABG) remains to be determined. Objectives The purpose of this study was to evaluate the association between age and BITA versus SITA outcomes in the Arterial Revascularization Trial. Methods The primary endpoints were all-cause mortality and a composite of major adverse events, including all-cause mortality, myocardial infarction, or stroke. Secondary endpoints were bleeding complications and sternal wound complications up to 6 months after surgery. Multivariable fractional polynomials analysis and log-rank tests were used. Results Age did not affect any of the explored outcomes in the overall BITA versus SITA comparison in the intention-to-treat analysis and in the analysis based on the number of arterial grafts received. However, when the intention-to-treat analysis was restricted to the populations of patients between age 50 and 70 years, younger patients in the BITA arm had a significantly lower incidence of major adverse events (p = 0.03). Conclusions Our results suggest that BITA may improve long-term outcome in younger patients, although more randomized data are needed to confirm this hypothesis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Bypass grafting
Myocardial Infarction
Coronary surgery
Hemorrhage
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
Humans
030212 general & internal medicine
Myocardial infarction
Thoracic artery
Coronary Artery Bypass
Adverse effect
Stroke
Internal Mammary-Coronary Artery Anastomosis
Aged
Aged, 80 and over
business.industry
Age Factors
Middle Aged
medicine.disease
Intention to Treat Analysis
Arterial grafts
Arterial revascularization
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....82fdbf2dc16f140ad5bf751f98a1cc67