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A study of critically ill children presenting with seizures regardless of seizure duration admitted in the PICU of a tertiary hospital in India
- Source :
- Epilepsy & Behavior Reports, Vol 14, Iss, Pp 100382-(2020), Epilepsy & Behavior Reports
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Our aim was to study the clinical profile, immediate outcome and risk factors associated with poor outcome in critically ill children presenting with seizures requiring PICU admission. As seizures lasting 10 min or more can potentially cause brain damage, we included all children regardless of seizure duration. The records of 157 children aged 1 month to 16 years admitted in the PICU at a tertiary hospital in India with seizures as the presenting symptom during a three-year period were studied retrospectively. Median age of patients was 4 years. 34 (21%) had pre-existing epilepsy and 33 (21%) had previous developmental delay/neuro-deficit. Seizure duration was > 30 min in 75 (47.7%) and 56 (35.6%) required the use of more than 2 antiseizure drugs. 101 (64%) had acute symptomatic seizures, 28 (17%) remote symptomatic and 27 (17.1%) had unknown cause. New onset neurological deficit was seen in 18 (15.6%) and 14 (8.9%) died. Young age, high PEWS score at presentation, prolonged/recurrent seizures, CNS infection, need for multiple antiseizure drugs and ventilation/pressor use were risk factors for poor outcome. Neurological outcome and survival of children in our study were good. Further all-inclusive studies irrespective of seizure duration are needed to obtain a complete picture of critical children presenting with seizures.<br />Highlights • All critical children presenting with seizures were included irrespective of seizure duration • 52.2% patients had seizures lasting for less than 30 min • 28.6% patients had CNS infection as the underlying etiology • Short-term neurological outcome was comparable to previous reports • Mortality associated with status epilepticus was lower than that reported by other Indian studies
- Subjects :
- Pediatrics
medicine.medical_specialty
ER, emergency room
Brain damage
Article
Pediatric status epilepticus
lcsh:RC346-429
New onset
Behavioral Neuroscience
Epilepsy
Seizures
Medicine
Pediatric intensive care unit
lcsh:Neurology. Diseases of the nervous system
Outcome
Neurological deficit
business.industry
Critically ill
lcsh:QP351-495
PEWS, Pediatric Early Warning Signs
SE, status epilepticus
Symptomatic seizures
medicine.disease
Young age
lcsh:Neurophysiology and neuropsychology
Neurology
ILAE, International League Against Epilepsy
Neurology (clinical)
medicine.symptom
business
Subjects
Details
- ISSN :
- 25899864
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Epilepsy & Behavior Reports
- Accession number :
- edsair.doi.dedup.....82ea5c4b85f71719f38dab82313fb4fe