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Fatigue and cognitive impairment after COVID-19: A prospective multicentre study
- Source :
- EClinicalMedicine 53, 101651 (2022). doi:10.1016/j.eclinm.2022.101651
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Reliable estimates of frequency, severity and associated factors of both fatigue and cognitive impairment after COVID-19 are needed. Also, it is not clear whether the two are distinct sequelae of COVID-19 or part of the same syndrome.'In this prospective multicentre study, frequency of post-COVID fatigue and cognitive impairment were assessed in n = 969 patients (535 [55%] female) ≥6 months after SARS-CoV-2 infection with the FACIT-Fatigue scale (cut-off ≤30) and Montreal Cognitive Assessment (≤25 mild, ≤17 moderate impairment) between November 15, 2020 and September 29, 2021 at University Medical Center Schleswig-Holstein, Campus Kiel and University Hospital Würzburg in Germany. 969 matched non-COVID controls were drawn from a pre-pandemic, randomised, Germany-wide population survey which also included the FACIT-Fatigue scale. Associated sociodemographic, comorbid, clinical, psychosocial factors and laboratory markers were identified with univariate and multivariable linear regression models.On average 9 months after infection, 19% of patients had clinically relevant fatigue, compared to 8% of matched non-COVID controls (p < 0.001). Factors associated with fatigue were female gender, younger age, history of depression and the number of acute COVID symptoms. Among acute COVID symptoms, altered consciousness, dizziness and myalgia were most strongly associated with long-term fatigue. Moreover, 26% of patients had mild and 1% had moderate cognitive impairment. Factors associated with cognitive impairment were older age, male gender, shorter education and a history of neuropsychiatric disease. There was no significant correlation between fatigue and cognitive impairment and only 5% of patients suffered from both conditions.Fatigue and cognitive impairment are two common, but distinct sequelae of COVID-19 with potentially separate pathophysiological pathways.German Federal Ministry of Education and Research (BMBF).
- Subjects :
- NAPKON, National Pandemic Cohort Network
MoCA, Montreal Cognitive Assessment
PSQI, Pittsburgh Sleep Quality Index
SARS-CoV-2
PHQ-8, 8-item depression module of the Patient Health Questionnaire
COVID-19
VIF, variance inflation factor
General Medicine
CSF, cerebrospinal fluid
Post-acute COVID-19 syndrome
CI, confidence interval
PCR, polymerase chain reaction
Cognitive dysfunction
COVID-19, Coronavirus Disease 2019
SARS-CoV-2, Severe Acute Respiratory Distress Syndrome caused by Corona Virus 2
CRP, C-reactive protein
GAD-7, 7-item anxiety screening questionnaire
ddc:610
Fatigue
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- EClinicalMedicine 53, 101651 (2022). doi:10.1016/j.eclinm.2022.101651
- Accession number :
- edsair.doi.dedup.....82d9c2479534929a79b53945d9e776e2