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Regional Differences in Cerebral Glucose Metabolism After Cardiac Arrest and Resuscitation in Rats Using [(18)F]FDG Positron Emission Tomography and Autoradiography

Authors :
Alessandro Putzu 1
2
Silvia Valtorta 3
4
Giuseppe Di Grigoli 3
5
Matthias Haenggi 6
Sara Belloli 3
Antonio Malgaroli 7
Marco Gemma 1
Giovanni Landoni 1
Luigi Beretta 1
Rosa Maria Moresco 3
University of Zurich
Moresco, Rosa Maria
Putzu, A
Valtorta, S
Di Grigoli, G
Haenggi, M
Belloli, S
Malgaroli, A
Gemma, M
Landoni, G
Beretta, L
Moresco, R
Putzu, Alessandro
Valtorta, Silvia
Di Grigoli, Giuseppe
Haenggi, Matthia
Belloli, Sara
Malgaroli, Antonio
Gemma, Marco
Landoni, Giovanni
Beretta, Luigi
Source :
Putzu, Alessandro; Valtorta, Silvia; Di Grigoli, Giuseppe; Hänggi, Matthias; Belloli, Sara; Malgaroli, Antonio; Gemma, Marco; Landoni, Giovanni; Beretta, Luigi; Moresco, Rosa Maria (2018). Regional Differences in Cerebral Glucose Metabolism After Cardiac Arrest and Resuscitation in Rats Using [(18)F]FDG Positron Emission Tomography and Autoradiography. Neurocritical care, 28(3), pp. 370-378. Springer 10.1007/s12028-017-0445-0 , Neurocritical care (Online) 28 (2018): 370–378. doi:10.1007/s12028-017-0445-0, info:cnr-pdr/source/autori:Alessandro Putzu 1,2, Silvia Valtorta 3,4, Giuseppe Di Grigoli 3,5, Matthias Haenggi 6, Sara Belloli 3,5, Antonio Malgaroli 7, Marco Gemma 1,2, Giovanni Landoni 1,2, Luigi Beretta 1,2, Rosa Maria Moresco 3,4/titolo:Regional Differences in Cerebral Glucose Metabolism After Cardiac Arrest and Resuscitation in Rats Using [18F]FDG Positron Emission Tomography and Autoradiography./doi:10.1007%2Fs12028-017-0445-0/rivista:Neurocritical care (Online)/anno:2018/pagina_da:370/pagina_a:378/intervallo_pagine:370–378/volume:28
Publication Year :
2018
Publisher :
Springer, 2018.

Abstract

BACKGROUND Cardiac arrest is an important cause of morbidity and mortality. Brain injury severity and prognosis of cardiac arrest patients are related to the cerebral areas affected. To this aim, we evaluated the variability and the distribution of brain glucose metabolism after cardiac arrest and resuscitation in an adult rat model. METHODS Ten rats underwent 8-min cardiac arrest, induced with a mixture of potassium and esmolol, and resuscitation, performed with chest compressions and epinephrine. Eight sham animals received anesthesia and experimental procedures identical to the ischemic group except cardiac arrest induction. Brain metabolism was assessed using [(18)F]FDG autoradiography and small animal-dedicated positron emission tomography. RESULTS The absolute glucose metabolism measured with [(18)F]FDG autoradiography 2 h after cardiac arrest and resuscitation was lower in the frontal, parietal, occipital, and temporal cortices of cardiac arrest animals, showing, respectively, a 36% (p = 0.006), 32% (p = 0.016), 36% (p = 0.009), and 32% (p = 0.013) decrease compared to sham group. Striatum, hippocampus, thalamus, brainstem, and cerebellum showed no significant changes. Relative regional metabolism indicated a redistribution of metabolism from cortical area to brainstem and cerebellum. CONCLUSIONS Our data suggest that cerebral regions have different susceptibility to moderate global ischemia in terms of glucose metabolism. The neocortex showed a higher sensibility to hypoxia-ischemia than other regions. Other subcortical regions, in particular brainstem and cerebellum, showed no significant change compared to non-ischemic rats.

Details

Language :
English
Database :
OpenAIRE
Journal :
Putzu, Alessandro; Valtorta, Silvia; Di Grigoli, Giuseppe; H&#228;nggi, Matthias; Belloli, Sara; Malgaroli, Antonio; Gemma, Marco; Landoni, Giovanni; Beretta, Luigi; Moresco, Rosa Maria (2018). Regional Differences in Cerebral Glucose Metabolism After Cardiac Arrest and Resuscitation in Rats Using [(18)F]FDG Positron Emission Tomography and Autoradiography. Neurocritical care, 28(3), pp. 370-378. Springer 10.1007/s12028-017-0445-0 <http://dx.doi.org/10.1007/s12028-017-0445-0>, Neurocritical care (Online) 28 (2018): 370–378. doi:10.1007/s12028-017-0445-0, info:cnr-pdr/source/autori:Alessandro Putzu 1,2, Silvia Valtorta 3,4, Giuseppe Di Grigoli 3,5, Matthias Haenggi 6, Sara Belloli 3,5, Antonio Malgaroli 7, Marco Gemma 1,2, Giovanni Landoni 1,2, Luigi Beretta 1,2, Rosa Maria Moresco 3,4/titolo:Regional Differences in Cerebral Glucose Metabolism After Cardiac Arrest and Resuscitation in Rats Using [18F]FDG Positron Emission Tomography and Autoradiography./doi:10.1007%2Fs12028-017-0445-0/rivista:Neurocritical care (Online)/anno:2018/pagina_da:370/pagina_a:378/intervallo_pagine:370–378/volume:28
Accession number :
edsair.doi.dedup.....82d9001ad4c66c88e03db658eede7f35