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The macroecology of cancer incidences in humans is associated with large-scale assemblages of endemic infections
- Source :
- Infection, Genetics and Evolution, Infection, Genetics and Evolution, Elsevier, 2018, 61, pp.189-196. ⟨10.1016/j.meegid.2018.03.016⟩, Infection, Genetics and Evolution, 2018, 61, pp.189-196. 〈https://www.sciencedirect.com/science/article/pii/S1567134818301163?via%3Dihub〉. 〈10.1016/j.meegid.2018.03.016〉
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- 8 pages; International audience; It is now well supported that 20% of human cancers have an infectious causation (i.e., oncogenic agents). Accumulating evidence suggests that aside from this direct role, other infectious agents may also indirectly affect cancer epidemiology through interactions with the oncogenic agents within the wider infection community. Here, we address this hypothesis via analysis of large-scale global data to identify associations between human cancer incidence and assemblages of neglected infectious agents. We focus on a gradient of three widely-distributed cancers with an infectious cause: bladder (~2% of recorded cancer cases are due to Shistosoma haematobium), liver (~60% consecutive to Hepatitis B and C infection) and stomach (Helicobacter pylori is associated with ~70% of cases). We analyzed countries in tropical and temperate regions separately, and controlled for many confounding social and economic variables. First, we found that particular assemblages of bacteria are associated with bladder cancer incidences. Second, we observed a specific and robust association between helminths and liver cancer incidences in both biomes. Third, we show that certain assemblages of viruses may facilitate stomach cancer in tropical area, while others protect against its development in temperate countries. Finally, we discuss the implications of our results in terms of cancer prevention and highlight the necessity to consider neglected diseases, especially in tropics, to adapt public health strategies against infectious diseases and cancer.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Endemic Diseases
[SDV.CAN]Life Sciences [q-bio]/Cancer
Microbiology
Biomes
Helicobacter Infections
[ SDV.CAN ] Life Sciences [q-bio]/Cancer
03 medical and health sciences
Schistosomiasis haematobia
Environmental health
Neoplasms
Pathogen-cancer interactions
Epidemiology of cancer
Genetics
medicine
[ SDV.EE.IEO ] Life Sciences [q-bio]/Ecology, environment/Symbiosis
Animals
Humans
Stomach cancer
Molecular Biology
Data mining
Ecology, Evolution, Behavior and Systematics
Human cancer incidences
Bladder cancer
Cancer prevention
biology
Incidence
Cancer
Helicobacter pylori
Hepatitis B
medicine.disease
biology.organism_classification
Hepatitis C
3. Good health
030104 developmental biology
Infectious Diseases
Neglected diseases
Host-Pathogen Interactions
Female
Public Health
Public health strategies
Liver cancer
[SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis
Subjects
Details
- Language :
- English
- ISSN :
- 15671348 and 15677257
- Database :
- OpenAIRE
- Journal :
- Infection, Genetics and Evolution, Infection, Genetics and Evolution, Elsevier, 2018, 61, pp.189-196. ⟨10.1016/j.meegid.2018.03.016⟩, Infection, Genetics and Evolution, 2018, 61, pp.189-196. 〈https://www.sciencedirect.com/science/article/pii/S1567134818301163?via%3Dihub〉. 〈10.1016/j.meegid.2018.03.016〉
- Accession number :
- edsair.doi.dedup.....82d6ec868ea1ce78085dcd38091b839f