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Classification of drugs for evaluating drug interaction in drug development and clinical management
- Source :
- Drug Metabolism and Pharmacokinetics. 41:100414
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- During new drug development, clinical drug interaction studies are carried out in accordance with the mechanism of potential drug interactions evaluated by in vitro studies. The obtained information should be provided efficiently to medical experts through package inserts and various information materials after the drug's launch. A recently updated Japanese guideline presents general procedures that are considered scientifically valid at the present moment. In this review, we aim to highlight the viewpoints of the Japanese guideline and enumerate drugs that were involved or are anticipated to be involved in evident pharmacokinetic drug interactions and classify them by their clearance pathway and potential intensity based on systematic reviews of the literature. The classification would be informative for designing clinical studies during the development stage, and the appropriate management of drug interactions in clinical practice.
- Subjects :
- Pharmacology
Drug
medicine.medical_specialty
Clinical pharmacology
Package insert
business.industry
Mechanism (biology)
media_common.quotation_subject
Pharmaceutical Science
Guideline
Drug interaction
law.invention
Systematic review
Drug Development
Pharmaceutical Preparations
Drug development
law
Medicine
Drug Interactions
Pharmacology (medical)
Medical physics
business
media_common
Subjects
Details
- ISSN :
- 13474367
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Drug Metabolism and Pharmacokinetics
- Accession number :
- edsair.doi.dedup.....82ce1e1a3c01a086860e8f1e04f6036e