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Bone healing of commercial oral implants with RGD immobilization through electrodeposited poly(ethylene glycol) in rabbit cancellous bone
- Source :
- Acta Biomaterialia. 7:3222-3229
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Immobilization of RGD peptides on titanium (Ti) surfaces enhances implant bone healing by promoting early osteoblastic cell attachment and subsequent differentiation by facilitating integrin binding. Our previous studies have demonstrated the efficacy of RGD peptide immobilization on Ti surfaces through the electrodeposition of poly(ethylene glycol) (PEG) (RGD/PEG/Ti), which exhibited good chemical stability and bonding. The RGD/PEG/Ti surface promoted differentiation and mineralization of pre-osteoblasts. This study investigated the in vivo bone healing capacity of the RGD/PEG/Ti surface for biomedical application as a more osteoconductive implant surface in dentistry. The RGD/PEG/Ti surface was produced on an osteoconductive implant surface, i.e. the grit blasted micro-rough surface of a commercial oral implant. The osteoconductivity of the RGD/PEG/Ti surface was compared by histomorphometric evaluation with an RGD peptide-coated surface obtained by simple adsorption in rabbit cancellous bone after 2 and 4 weeks healing. The RGD/PEG/Ti implants displayed a high degree of direct bone apposition in cancellous bone and achieved greater active bone apposition, even in areas of poor surrounding bone. Significant increases in the bone to implant contact percentage were observed for RGD/PEG/Ti implants compared with RGD-coated Ti implants obtained by simple adsorption both after 2 and 4 weeks healing (P
- Subjects :
- Male
Materials science
Surface Properties
Biomedical Engineering
chemistry.chemical_element
Bone healing
Biochemistry
Bone and Bones
Osseointegration
Polyethylene Glycols
Prosthesis Implantation
Biomaterials
chemistry.chemical_compound
PEG ratio
medicine
Animals
Molecular Biology
Integrin binding
Dental Implants
Wound Healing
General Medicine
Electroplating
Immobilized Proteins
medicine.anatomical_structure
chemistry
Microscopy, Electron, Scanning
Rabbits
Implant
Oligopeptides
Ethylene glycol
Cancellous bone
Biotechnology
Biomedical engineering
Titanium
Subjects
Details
- ISSN :
- 17427061
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Acta Biomaterialia
- Accession number :
- edsair.doi.dedup.....82c8562aaa59cce3aa80d1d6aaffb8f3