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Electroencephalographic theta activity and cognition in schizophrenia: preliminary results

Authors :
Michał Jarkiewicz
Wojciech Jernajczyk
Małgorzata Jędrasik-Styła
Aleksandra Wierzbicka
Adam Wichniak
Magdalena Linke
Łukasz Okruszek
Marek Jarema
Agnieszka Ciołkiewicz
Source :
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 16(3)
Publication Year :
2014

Abstract

MATRICS Consensus Cognitive Battery (MCCB) is a contemporary standard for assessment of cognitive functions in schizophrenia. The aim of the study was to examine the association between electroencephalographic spectral power and a wide range of cognitive functions measured with MCCB.Thirty-nine patients with schizophrenia (27 male, mean age 28.2 ± 5.2 years) underwent EEG recordings and were assessed with MCCB. The EEG recordings were visually inspected and manually cleaned from artifacts and subjected to spectral analysis with EEGlab. Absolute and relative power as percentage of total spectral power were computed for frequency ranges from 0.5 to 30 Hz. To compare spectral power in patients with various cognitive functioning, patients from best and worst MCCB quartiles were selected.Superior cognitive performance was associated with less power of theta waves. Six MCCB cognitive tests showed significant correlations with absolute theta power and three tests with relative theta power. The correlation coefficients between MCCB composite score and theta power were rp = -0.45 for absolute and rp = -0.36 for relative values. Increased theta power was linked especially to memory deficits.These preliminary results suggest that electroencephalographic resting state theta power is an indicator of cognitive deficit in patients with schizophrenia.

Details

ISSN :
18141412
Volume :
16
Issue :
3
Database :
OpenAIRE
Journal :
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
Accession number :
edsair.doi.dedup.....82c6bd866743cb24e33e27bd8fc16ccf