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Discovery of Hepatitis C Virus NS3 Helicase Inhibitors by a Multiplexed, High-Throughput Helicase Activity Assay Based on Graphene Oxide
- Source :
- Angewandte Chemie (Weinheim an Der Bergstrasse, Germany), Angewandte Chemie (International Ed. in English)
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- A GO‐to solution: A simple graphene oxide (GO)‐based assay to screen for selective inhibitors of a hepatitis C virus (HCV) helicase along with inhibitors of a severe acute respiratory syndrome coronavirus (SARS CoV) helicase was tested (see scheme). A single screen found five inhibitors highly selective for the HCV helicase orthologous to the SARS CoV helicase. Some of these hits were validated using the same GO‐based assay.WILEY-VCH
- Subjects :
- Hochdurchsatz‐Screening
Helicasen
viruses
Hepatitis C virus
High-throughput screening
Hepacivirus
Viral Nonstructural Proteins
Multiplexassays
medicine.disease_cause
high‐throughput screening
Zuschrift
Catalysis
Telaprevir
Biosensoren
Inhibitory Concentration 50
chemistry.chemical_compound
Interferon
Wirkstoff‐Forschung
Drug Discovery
medicine
Humans
Protease Inhibitors
Cells, Cultured
Graphenoxid
biology
Drug discovery
Chemistry
Communication
Ribavirin
fungi
helicases
virus diseases
Helicase
Oxides
General Medicine
Zuschriften
General Chemistry
biosensors
biology.organism_classification
Molecular biology
Communications
multiplex assays
biology.protein
graphene oxide
Biological Assay
Graphite
medicine.drug
Subjects
Details
- ISSN :
- 14337851
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie International Edition
- Accession number :
- edsair.doi.dedup.....82c1f7cb4be202eecc6ae11bdc7f76b3
- Full Text :
- https://doi.org/10.1002/anie.201209222