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Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering
- Source :
- Nanotechnology Reviews, Vol 3, Iss 6, Pp 527-552 (2014)
- Publication Year :
- 2014
- Publisher :
- Walter de Gruyter GmbH, 2014.
-
Abstract
- Critical-sized bone defects have, in many cases, posed challenges to the current gold standard treatments. Bioactive glasses are reported to be able to stimulate more bone regeneration than other bioactive ceramics; however, the difficulty in producing porous scaffolds made of bioactive glasses has limited their extensive use in bone regeneration. On the other hand, calcium phosphate ceramics such as synthetic hydroxyapatite and tricalcium phosphate are widely used in the clinic, but they stimulate less bone regeneration. This paper gives an overview of the recent developments in the field of bioactive nanoparticles, with a focus on nanohydroxyapatite and bioactive glasses for bone repair and regeneration. First, a brief overview of the chemical structure and common methods used to produce synthetic nanohydroxyapatite and bioactive glasses has been presented. The main body of the paper covers the physical and biological properties of these biomaterials, as well as their composites with biodegradable polymers used in bone regeneration. A summary of existing challenges and some recommendations for future directions have been brought in the concluding section of this paper.
- Subjects :
- Technology
Materials science
Materials processing
Chemical technology
Process Chemistry and Technology
Physical and theoretical chemistry
QD450-801
hydroxyapatite
Energy Engineering and Power Technology
Medicine (miscellaneous)
Industrial chemistry
Nanotechnology
TP1-1185
Bone tissue engineering
Surfaces, Coatings and Films
Nanomaterials
Biomaterials
Bioglass 45S5
bioglass® 45s5
nanoparticles
3d scaffold
bone tissue engineering
Biotechnology
Subjects
Details
- ISSN :
- 21919097 and 21919089
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Nanotechnology Reviews
- Accession number :
- edsair.doi.dedup.....82b82a175160d74592f3bedd9c47dc66