Back to Search Start Over

Gut microbiota‐derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling

Authors :
Li-Wei, Liu
Yu, Xie
Guan-Qun, Li
Tao, Zhang
Yu-Hang, Sui
Zhong-Jie, Zhao
Yang-Yang, Zhang
Wen-Bo, Yang
Xing-Long, Geng
Dong-Bo, Xue
Hua, Chen
Yong-Wei, Wang
Tian-Qi, Lu
Li-Ren, Shang
Zhi-Bo, Li
Le, Li
Bei, Sun
Source :
British Journal of Pharmacology. 180:647-666
Publication Year :
2022
Publisher :
Wiley, 2022.

Abstract

Gut microbiota dysbiosis induced by acute pancreatitis (AP) exacerbates pancreatic injury and systemic inflammatory responses. The alleviation of gut microbiota dysbiosis through faecal microbiota transplantation (FMT) is considered a potential strategy to reduce tissue damage and inflammation in many clinical disorders. Here, we aim to investigate the effect of gut microbiota and microbiota-derived metabolites on AP and further clarify the mechanisms associated with pancreatic damage and inflammation.AP rat and mouse models were established by administration of caerulein or sodium taurocholate in vivo. Pancreatic acinar cells were exposed to caerulein and lipopolysaccharide in vitro to simulate AP.Normobiotic FMT alleviated AP-induced gut microbiota dysbiosis and ameliorated the severity of AP, including mitochondrial dysfunction, oxidative damage and inflammation. Normobiotic FMT induced higher levels of NADGut microbiota-derived NMN alleviates the severity of AP by activating the SIRT3-PRDX5 pathway. Normobiotic FMT could be served as a potential strategy for AP treatment.

Subjects

Subjects :
Pharmacology

Details

ISSN :
14765381 and 00071188
Volume :
180
Database :
OpenAIRE
Journal :
British Journal of Pharmacology
Accession number :
edsair.doi.dedup.....82a2ceea551963dd389d79ae333ac5d5