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Motor axon excitability measures in the rat tail are the same awake or anaesthetized using sodium pentobarbital
- Publication Year :
- 2019
- Publisher :
- Cold Spring Harbor Laboratory, 2019.
-
Abstract
- BackgroundNerve excitability tests in sciatic motor axons are sensitive to anaesthetic choice. Results using ketamine/xylazine (KX) are different from those using sodium pentobarbital (SP). It is not clear which results are most similar to the awake condition, though results using SP appear more similar to human results.MethodsNerve excitability in tail motor axons was tested in 8 adult female rats with a chronic sacral spinal cord injury. These animals have no behavioural response to electrical stimulation of the tail and were tested awake and then anaesthetized using SP.ResultsThe nerve excitability test results in the awake condition were indistinguishable from the results when the same rats were anaesthetized with sodium pentobarbital. Summary plots of the test results overlap within the boundaries of the standard error and paired t-tests on the 42 discrete measures generated by nerve excitability testing yielded no significant differences (after Bonferroni correction for multiple comparisons).ConclusionsNerve excitability test results in rat motor axons are the same whether the animals are awake or anesthetized using sodium pentobarbital.
- Subjects :
- 0303 health sciences
Adult female
business.industry
Stimulation
Sodium pentobarbital
Rat tail
Xylazine
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Anesthesia
Medicine
Ketamine
Axon
business
Sacral spinal cord
030217 neurology & neurosurgery
030304 developmental biology
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....829a8cd1b334a916aa8345a65b47429b