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Aortic wall thickness in newborns with intrauterine growth restriction

Authors :
Michael R. Skilton
Jason A. Harmer
Kaye A. Griffiths
David S. Celermajer
Nick Evans
Source :
The Lancet. 365:1484-1486
Publication Year :
2005
Publisher :
Elsevier BV, 2005.

Abstract

Much epidemiological evidence has linked low birthweight with late cardiovascular risk. We measured aortic wall thickness (a marker of early atherosclerosis) by ultrasonography in 25 newborn babies with intrauterine growth restriction and 25 with normal birthweight. Maximum aortic thicknesses were significantly higher in the babies with intrauterine growth restriction (810 microm [SD 113]) than in those without (743 microm [76], p=0.02), more so after adjustment for birthweight (300 microm/kg [45] vs 199 microm/kg [29], p0.0001). Newborn babies with growth restriction have significant aortic thickening, suggesting that prenatal events might predispose to later cardiovascular risk.

Details

ISSN :
01406736
Volume :
365
Database :
OpenAIRE
Journal :
The Lancet
Accession number :
edsair.doi.dedup.....8295513265d6b59985a39b8851b5148b
Full Text :
https://doi.org/10.1016/s0140-6736(05)66419-7