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Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients
- Source :
- Nutrients; Volume 14; Issue 10; Pages: 2153
- Publication Year :
- 2022
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2022.
-
Abstract
- Background: Extra virgin olive oil (EVOO) improves post-prandial glycemia, but the underlying mechanism has not been fully elucidated. We tested the hypothesis that EVOO improves post-prandial glycemia by reducing gut permeability-derived low-grade endotoxemia. Methods: Serum levels of lipopolysaccharides (LPS), zonulin, a marker of gut permeability, glucose, insulin and glucagon-like peptide 1 (GLP1) were measured in 20 patients with impaired fasting glucose (IFG) and 20 healthy subjects (HS) matched for sex and age. The same variables were measured in IFG patients (n = 20) and HS (n = 20) before and after a Mediterranean diet with 10 g EVOO added or not (n = 20) or in IFG patients (n = 20) before and after intake of 40 g chocolate with EVOO added or not. Results: Compared to HS, IFG had higher levels of LPS and zonulin. In HS, meal intake was associated with a significant increase of blood glucose, insulin, and GLP1 with no changes of blood LPS and zonulin. Two hours after a meal intake containing EVOO, IFG patients showed a less significant increase of blood glucose, a more marked increase of blood insulin and GLP1 and a significant reduction of LPS and zonulin compared to IFG patients not given EVOO. Correlation analysis showed that LPS directly correlated with blood glucose and zonulin and inversely with blood insulin. Similar findings were detected in IFG patients given a chocolate added or without EVOO. Conclusion: Addition of EVOO to a Mediterranean diet or chocolate improves gut permeability and low-grade endotoxemia.
- Subjects :
- Blood Glucose
Lipopolysaccharides
Nutrition and Dietetics
lipopolysaccharides (LPS)
endocrine system diseases
gut permeability
zonulin
Glucagon-like peptide1(GLP1)
extra virgin olive oil (EVOO)
oleuropein
Impaired fasting glucose (IFG)
digestive, oral, and skin physiology
nutritional and metabolic diseases
Endotoxemia
Permeability
glucagon-like peptide1(GLP1)
Prediabetic State
Glucagon-Like Peptide 1
Diabetes Mellitus
Humans
Insulin
Olive Oil
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Database :
- OpenAIRE
- Journal :
- Nutrients; Volume 14; Issue 10; Pages: 2153
- Accession number :
- edsair.doi.dedup.....828fd8661405060f145c0799fb82e0f7
- Full Text :
- https://doi.org/10.3390/nu14102153