The tissue residues of sodium dehydroacetate used as feed preservative in swine

BACKGROUND Sodium dehydroacetate (Na-DHA) is a food and feed additive with antimicrobial effects. There is little information on Na-DHA residue levels in foods derived from animals. In this study, Na-DHA residue levels in swine tissues were determined by HLPC, and the pharmacokinetics of Na-DHA in tissues were determined. RESULTS The Na-DHA residue levels in swine tissues were liver > muscle > fat. The pharmacokinetics of Na-DHA followed a binomial regression model, and the halftime of Na-DHA in swine tissues was 9.07 d for kidney, 7.19 d for liver, 6.66 d for muscle, and 5.39 d for fat tissue. The accuracy of the HPLC method for Na-DHA determination ranged from 80.18 to 91.33% recovery, with coefficients of variation < 6.4%, limit of detection of 0.08 mg kg-1, and limit of quantification of 0.2 mg kg-1. CONCLUSION Na-DHA included at 200 mg kg-1 in a swine diet is a safe feed additive based on residue elimination and ADI values reported.