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Types of second primary cancer influence overall survival in cutaneous melanoma
- Source :
- BMC Cancer, BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
-
Abstract
- Background Favorable survival in malignant cutaneous melanoma (melanoma) has increased the likelihood of second primary cancer (SPC). We assess the influence of patient characteristics at diagnosis of first melanoma and the type of SPC (second melanoma and other SPC) on overall survival. Methods We used the Swedish Cancer Registry data to assess overall survival in melanoma for the period 1990 to 2015. Kaplan-Meier curves were plotted and hazard ratios (HRs) were estimated with Cox regression models by considering SPC diagnosis as a time-dependent variable. Results A total of 46,726 patients were diagnosed with melanoma, and 15.3% of them developed SPC, among which, two thirds were other SPCs. Second melanomas were diagnosed early (31% during the first year) compared to non-melanoma SPCs (9.5%). Survival for women with second melanoma or other SPC (56 and 21% alive after 25 years of follow-up, respectively) exceeded the male rates (21 and 10%, respectively) but all these figures were lower than for females (60% alive) or males (48%) without SPC. Time dependent analysis showed vastly increased HRs for cancer types that are fatal also as first cancers, but SPC-specific HRs remained relatively uniform, irrespective of SPC diagnosed soon or late after first melanoma. In early-onset melanoma, SPC diagnosis after 10 years may not negatively influence overall survival. Conclusions As the overall survival of patients with many types of SPCs is unfavorable, advice about health lifestyle should benefit smoking patients and early detection methods may be recommended for SPCs of the breast, prostate and colorectum.
- Subjects :
- Oncology
Male
Cancer Research
Skin Neoplasms
Time Factors
Kaplan-Meier Estimate
MALIGNANT-MELANOMA
Second melanoma
0302 clinical medicine
Cancer Survivors
Prostate
Surgical oncology
SWEDEN
Overall survival
Registries
Melanoma
RC254-282
Aged, 80 and over
RISK
0303 health sciences
Time-dependent analysis
IN-SITU
Hazard ratio
Smoking
Age Factors
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Neoplasms, Second Primary
Middle Aged
Prognosis
TUMORS
3. Good health
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
Independent primary
medicine.medical_specialty
animal structures
3122 Cancers
03 medical and health sciences
Sex Factors
Internal medicine
Genetics
medicine
Humans
030304 developmental biology
Aged
Proportional Hazards Models
Proportional hazards model
business.industry
Research
fungi
Cancer
NATIONWIDE
medicine.disease
TRENDS
Cancer registry
Cutaneous melanoma
GENDER
business
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....827a741e7f643ed1014a1bd0b6d4ac0b
- Full Text :
- https://doi.org/10.1186/s12885-021-08845-x