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Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America
- Source :
- Nature Communications, Nature Communications, 2022, 13 (1), pp.7490. ⟨10.1038/s41467-022-34970-7⟩
- Publication Year :
- 2022
- Publisher :
- Springer Science and Business Media LLC, 2022.
-
Abstract
- Funder: Genomics Research and Development Initiative (Government of Canada), the German Federal Ministry of Education and Research (BMBF) grant no. 01KI1709, the French Agency for food environmental and occupational health & safety (Anses), and the French National Reference Center (CNR) for antimicrobial resistance.<br />Extended-spectrum cephalosporins (ESCs) are critically important antimicrobial agents for human and veterinary medicine. ESC resistance (ESC-R) genes have spread worldwide through plasmids and clonal expansion, yet the distribution and dynamics of ESC-R genes in different ecological compartments are poorly understood. Here we use whole genome sequence data of Enterobacterales isolates of human and animal origin from Europe and North America and identify contrasting temporal dynamics. AmpC β-lactamases were initially more dominant in North America in humans and farm animals, only later emerging in Europe. In contrast, specific extended-spectrum β-lactamases (ESBLs) were initially common in animals from Europe and later emerged in North America. This study identifies differences in the relative importance of plasmids and clonal expansion across different compartments for the spread of different ESC-R genes. Understanding the mechanisms of transmission will be critical in the design of interventions to reduce the spread of antimicrobial resistance.
- Subjects :
- Multidisciplinary
Cephalosporin Resistance
General Physics and Astronomy
500 Naturwissenschaften und Mathematik::570 Biowissenschaften
Biologie::570 Biowissenschaften
Biologie
General Chemistry
Antimicrobial resistance
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
beta-Lactamases
General Biochemistry, Genetics and Molecular Biology
Anti-Bacterial Agents
Cephalosporins
Bacterial genetics
Escherichia coli
Animals
Humans
Bacterial genomics
Phylogeny
Escherichia coli Infections
Plasmids
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....8270ad10f8cdf704cea6b03fd7f7647e