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Reply to Kardos et al.: Estimation of inbreeding depression from SNP data

Authors :
Bruce S. Weir
Zhihong Zhu
Jian Yang
Loic Yengo
Naomi R. Wray
Peter M. Visscher
Matthew R. Robinson
Publication Year :
2018
Publisher :
National Academy of Sciences, 2018.

Abstract

We thank Kardos et al. (1) for their interest in our study (2), which is about the detection and quantification of inbreeding depression (ID) for complex traits from SNP data. Kardos et al. (1) make a number of points about the utility and interpretation of estimates of ID from runs of homozygosity (FROH) compared with frequency-based inbreeding measures, such as the FUNI measure (3) that estimates the correlation between uniting gametes. First, Kardos et al. (1) say that FROH can be interpreted as a probability of identity-by-descent (IBD). However, in a random sample from a human population, the distribution of FROH will reflect both finite population size and occasionally pedigree inbreeding. In the absence of a well-defined base … [↵][1]1To whom correspondence may be addressed. Email: l.yengodimbou{at}uq.edu.au or peter.visscher{at}uq.edu.au. [1]: #xref-corresp-1-1

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....826b01a24fe0ed9a5d061d32f0466835