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Reply to Kardos et al.: Estimation of inbreeding depression from SNP data
- Publication Year :
- 2018
- Publisher :
- National Academy of Sciences, 2018.
-
Abstract
- We thank Kardos et al. (1) for their interest in our study (2), which is about the detection and quantification of inbreeding depression (ID) for complex traits from SNP data. Kardos et al. (1) make a number of points about the utility and interpretation of estimates of ID from runs of homozygosity (FROH) compared with frequency-based inbreeding measures, such as the FUNI measure (3) that estimates the correlation between uniting gametes. First, Kardos et al. (1) say that FROH can be interpreted as a probability of identity-by-descent (IBD). However, in a random sample from a human population, the distribution of FROH will reflect both finite population size and occasionally pedigree inbreeding. In the absence of a well-defined base … [↵][1]1To whom correspondence may be addressed. Email: l.yengodimbou{at}uq.edu.au or peter.visscher{at}uq.edu.au. [1]: #xref-corresp-1-1
- Subjects :
- 0301 basic medicine
Estimation
Snp data
education.field_of_study
Multidisciplinary
Inbreeding Depression
Population size
Population
Genomics
Runs of Homozygosity
Pedigree
03 medical and health sciences
Consanguinity
030104 developmental biology
Statistics
Inbreeding depression
Letters
10. No inequality
education
Inbreeding
Mathematics
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....826b01a24fe0ed9a5d061d32f0466835