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Omega-3 fatty acids alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration
- Source :
- Metabolic brain disease. 29(1)
- Publication Year :
- 2013
-
Abstract
- Studies have consistently reported the participation of oxidative stress in bipolar disorder (BD). Evidences indicate that omega-3 (ω3) fatty acids play several important roles in brain development and functioning. Moreover, preclinical and clinical evidence suggests roles for ω3 fatty acids in BD. Considering these evidences, the present study aimed to investigate the effects of ω3 fatty acids on locomotor behavior and oxidative stress parameters (TBARS and protein carbonyl content) in brain of rats subjected to an animal model of mania induced by fenproporex. The fenproporex treatment increased locomotor behavior in saline-treated rats under reversion and prevention model, and ω3 fatty acids prevented fenproporex-related hyperactivity. Moreover, fenproporex increased protein carbonyls in the prefrontal cortex and cerebral cortex, and the administration of ω3 fatty acids reversed this effect. Lipid peroxidation products also are increased in prefrontal cortex, striatum, hippocampus and cerebral after fenproporex administration, but ω3 fatty acids reversed this damage only in the hippocampus. On the other hand, in the prevention model, fenproporex increased carbonyl content only in the cerebral cortex, and administration of ω3 fatty acids prevented this damage. Additionally, the administration of fenproporex resulted in a marked increased of TBARS in the prefrontal cortex, hippocampus, striatum and cerebral cortex, and prevent this damage in the prefrontal cortex, hippocampus and striatum. In conclusion, we are able to demonstrate that fenproporex-induced hyperlocomotion and damage through oxidative stress were prevented by ω3 fatty acids. Thus, the ω3 fatty acids may be important adjuvant therapy of bipolar disorder.
- Subjects :
- Male
medicine.medical_specialty
Bipolar Disorder
Presynaptic Terminals
Hippocampus
Striatum
Hyperkinesis
medicine.disease_cause
Biochemistry
Thiobarbituric Acid Reactive Substances
Antioxidants
Lipid peroxidation
Protein Carbonylation
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Internal medicine
Fatty Acids, Omega-3
medicine
TBARS
Animals
Rats, Wistar
Prefrontal cortex
Behavior, Animal
Amphetamines
Brain
Fenproporex
Rats
Disease Models, Animal
Oxidative Stress
Endocrinology
medicine.anatomical_structure
chemistry
Cerebral cortex
Exploratory Behavior
Neurology (clinical)
Lipid Peroxidation
Oxidative stress
medicine.drug
Subjects
Details
- ISSN :
- 15737365
- Volume :
- 29
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Metabolic brain disease
- Accession number :
- edsair.doi.dedup.....82504351763f8947b0b17c9aca2605a9