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Persistent symptoms and lab abnormalities in patients who recovered from COVID-19
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- With increasing numbers of patients recovering from COVID-19, there is increasing evidence for persistent symptoms and the need for follow-up studies. This retrospective study included patients without comorbidities, who recovered from COVID-19 and attended an outpatient clinic at a university hospital for follow-up care and potential convalescent plasma donation. Network analysis was applied to visualize symptom combinations and persistent symptoms. Comprehensive lab-testing was ascertained at each follow-up to analyze differences regarding patients with vs without persistent symptoms. 116 patients were included, age range was 18–69 years (median: 41) with follow-ups ranging from 22 to 102 days. The three most frequent persistent symptoms were Fatigue (54%), Dyspnea (29%) and Anosmia (25%). Lymphopenia was present in 13 of 112 (12%) cases. Five of 35 cases (14%) had Lymphopenia in the later follow-up range of 80–102 days. Serum IgA concentration was the only lab parameter with significant difference between patients with vs without persistent symptoms with reduced serum IgA concentrations in the patient cohort of persistent symptoms (p = 0.0219). Moreover, subgroup analyses showed that patients with lymphopenia experienced more frequently persistent symptoms. In conclusion, lymphopenia persisted in a noticeable percentage of recovered patients. Patients with persistent symptoms had significantly lower serum IgA levels. Furthermore, our data provides evidence that lymphopenia is associated with persistence of COVID-19 symptoms.
- Subjects :
- 0301 basic medicine
Immunoglobulin A
Adult
Male
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Adolescent
Anosmia
Science
Aftercare
Article
Persistence (computer science)
03 medical and health sciences
Young Adult
0302 clinical medicine
Medical research
Internal medicine
Germany
Lymphopenia
Virology
medicine
Outpatient clinic
Humans
030212 general & internal medicine
Young adult
Fatigue
Aged
Retrospective Studies
Multidisciplinary
biology
business.industry
SARS-CoV-2
Health care
COVID-19
Retrospective cohort study
Middle Aged
030104 developmental biology
Dyspnea
Cohort
biology.protein
Medicine
Female
medicine.symptom
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....82485600e0ed9a06ed842df64469fe07