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Elucidating opportunities and pitfalls in the treatment of experimental traumatic brain injury to optimize and facilitate clinical translation
- Source :
- Neuroscience & Biobehavioral Reviews. 85:160-175
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- The aim of this review is to discuss the research presented in a symposium entitled “Current progress in characterizing therapeutic strategies and challenges in experimental CNS injury” which was presented at the 2016 International Behavioral Neuroscience Society annual meeting. Herein we discuss diffuse and focal traumatic brain injury (TBI) and ensuing chronic behavioral deficits as well as potential rehabilitative approaches. We also discuss the effects of stress on executive function after TBI as well as the response of the endocrine system and regulatory feedback mechanisms. The role of the endocannabinoids after CNS injury is also discussed. Finally, we conclude with a discussion of antipsychotic and antiepileptic drugs, which are provided to control TBI-induced agitation and seizures, respectively. The review consists predominantly of published data.
- Subjects :
- 0301 basic medicine
Traumatic brain injury
Cognitive Neuroscience
medicine.medical_treatment
Maze learning
Behavioral neuroscience
Hippocampus
Article
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Brain Injuries, Traumatic
medicine
Animals
Humans
Maze Learning
Rehabilitation
Recovery of Function
medicine.disease
Cns injury
Disease Models, Animal
030104 developmental biology
Neuropsychology and Physiological Psychology
nervous system
Psychology
Neuroscience
030217 neurology & neurosurgery
Antipsychotic Agents
Focal traumatic brain injury
Subjects
Details
- ISSN :
- 01497634
- Volume :
- 85
- Database :
- OpenAIRE
- Journal :
- Neuroscience & Biobehavioral Reviews
- Accession number :
- edsair.doi.dedup.....824636debf7abb875d5023278cdff93e