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A Comparative Study on Aflatoxin B1 Metabolism in Mice and Rats
- Source :
- British Journal of Cancer
- Publication Year :
- 1971
-
Abstract
- In vivo metabolic studies on rats and mice revealed a marked difference in the fluorescent compounds produced after ingestion of aflatoxin B(1). The mouse converted aflatoxin B(1) to three unknown fluorescent compounds, designated x(1), x(2) and x(3) and the known aflatoxin M(1), while the rat was only capable of producing aflatoxin M(1). The results suggested that metabolites x(1), x(2), x(3) and aflatoxin M(1) were not part of a major metabolic pathway, but produced independently. These unknown yellowish-green fluorescent compounds did not seem to be conjugated with sulphate or glucuronic acid.In vitro incubations of various mouse liver cell fractions with aflatoxin B(1) showed that metabolites x(1), x(2), x(3) and aflatoxin M(1), could only be produced by the microsomal fraction and that NADPH was needed as a co-factor. The differences in aflatoxin metabolism by mice and rats are discussed in relation to the apparent resistance of the mouse to the carcinogenic effects of this toxin.
- Subjects :
- Male
Cancer Research
Aflatoxin
Chromatography, Paper
Ultraviolet Rays
Drug Resistance
Glucuronates
Biology
In Vitro Techniques
medicine.disease_cause
Cell Fractionation
Fluorescence
Absorption
chemistry.chemical_compound
Mice
Aflatoxins
Species Specificity
In vivo
Neoplasms
medicine
Animals
heterocyclic compounds
Mycotoxin
Carcinogen
Toxin
Sulfates
technology, industry, and agriculture
food and beverages
Articles
biological factors
Rats
Paper chromatography
Metabolic pathway
Oncology
Biochemistry
chemistry
Liver
Gastric Mucosa
Spectrophotometry
Microsome
Microsomes, Liver
Female
Chromatography, Thin Layer
NADP
Subjects
Details
- Language :
- English
- ISSN :
- 15321827 and 00070920
- Volume :
- 25
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....824146f1ded256b42af3915e70b14ec9