Back to Search
Start Over
The EBMT/EMCL consensus project on the role of autologous and allogeneic stem cell transplantation in mantle cell lymphoma
- Source :
- Leukemia. 29:464-473
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- The role of both autologous (autoSCT) and allogeneic stem cell transplantation (alloSCT) in the management of mantle cell lymphoma (MCL) remains to be clarified. We conducted a consensus project using the RAND-modified Delphi consensus procedure to provide guidance on how SCT should be used in MCL. With regard to autoSCT, there was consensus in support of: autoSCT is the standard first-line consolidation therapy; induction therapy should include high-dose cytarabine and Rituximab; complete or partial remission should be achieved before autoSCT; Rituximab maintenance following autoSCT is not indicated; and omission of autoSCT in 'low-risk' patients is not indicated. No consensus could be reached regarding: autoSCT in the treatment of relapsed disease following non-transplant therapy; the value of positron emission tomography scanning and minimal residual disease (MRD) monitoring; in vivo purging with Rituximab; total body irradiation conditioning for autoSCT; and preemptive Rituximab after autoSCT. For alloSCT, consensus was reached in support of: alloSCT should be considered for patients relapsing after autoSCT; reduced intensity conditioning regimens should be used; allogeneic immunotherapy should be used for MRD eradication after alloSCT; and there is a lack of prognostic criteria to guide the use of alloSCT as first-line consolidation. No consensus was reached regarding the role of alloSCT for relapsed disease following non-transplant therapy.
- Subjects :
- Cancer Research
medicine.medical_specialty
Neoplasm, Residual
Transplantation Conditioning
Consensus Development Conferences as Topic
Lymphoma, Mantle-Cell
Transplantation, Autologous
Antibodies, Monoclonal, Murine-Derived
Recurrence
hemic and lymphatic diseases
medicine
Humans
Transplantation, Homologous
business.industry
Remission Induction
Cytarabine
Hematopoietic Stem Cell Transplantation
Hematology
Total body irradiation
medicine.disease
Minimal residual disease
Surgery
Lymphoma
Europe
Transplantation
Treatment Outcome
Oncology
Positron-Emission Tomography
Monoclonal
Mantle cell lymphoma
Rituximab
Immunotherapy
business
Whole-Body Irradiation
medicine.drug
Subjects
Details
- ISSN :
- 14765551 and 08876924
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Leukemia
- Accession number :
- edsair.doi.dedup.....8221f85ac72538e26189bb1995624150